Cardiovascular Disease

Of all the diseases in which excess oxidative stress has been implicated, CVD has the strongest supporting evidence. Oxidation of low-density lipoprotein (LDL) cholesterol appears to be a key step in the development of atherosclerosis, a known risk factor in the development of CVD. Small studies have demonstrated reductions in LDL oxidation (mostly in vitro) following supplementation with dietary anti-oxidants (particularly vitamin E, which is primarily carried in LDL-cholesterol), suggesting that they may provide protection against the development of heart disease. A number of large intervention trials using disease outcomes (rather than biomarkers such as LDL oxidation) have also been conducted to try to demonstrate a protective effect of vitamin E, ,3-caro-tene, and, to a lesser extent, vitamin C supplements on cardiovascular disease. Most have been carried out in high-risk groups (e.g., smokers) or those with established heart disease (i.e., people with angina or who have already suffered a heart attack).

Your Heart and Nutrition

Your Heart and Nutrition

Prevention is better than a cure. Learn how to cherish your heart by taking the necessary means to keep it pumping healthily and steadily through your life.

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