Biliary excretion of biotin and metabolites is quantitatively negligible based on animal studies. When [14C]biotin was injected intravenously into rats, biotin, bisnorbiotin, biotin-d,l-sulfoxide, and bisnor-biotin methylketone accounted for less than 2% of the administered 14C, but urinary excretion accounted for 60%. Although the concentrations of biotin, bisnorbiotin, and biotin-d,l-sulfoxide were approximately 10-fold greater in bile than in serum of pigs, the bile-to-serum ratios of biotin and metabolites were more than 10-fold less than those of bilirubin, which is actively excreted in bile.
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