Biliary Excretion of Biotin and Metabolites

Biliary excretion of biotin and metabolites is quantitatively negligible based on animal studies. When [14C]biotin was injected intravenously into rats, biotin, bisnorbiotin, biotin-d,l-sulfoxide, and bisnor-biotin methylketone accounted for less than 2% of the administered 14C, but urinary excretion accounted for 60%. Although the concentrations of biotin, bisnorbiotin, and biotin-d,l-sulfoxide were approximately 10-fold greater in bile than in serum of pigs, the bile-to-serum ratios of biotin and metabolites were more than 10-fold less than those of bilirubin, which is actively excreted in bile.

Breaking Bulimia

Breaking Bulimia

We have all been there: turning to the refrigerator if feeling lonely or bored or indulging in seconds or thirds if strained. But if you suffer from bulimia, the from time to time urge to overeat is more like an obsession.

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