Biliary Excretion of Biotin and Metabolites

Biliary excretion of biotin and metabolites is quantitatively negligible based on animal studies. When [14C]biotin was injected intravenously into rats, biotin, bisnorbiotin, biotin-d,l-sulfoxide, and bisnor-biotin methylketone accounted for less than 2% of the administered 14C, but urinary excretion accounted for 60%. Although the concentrations of biotin, bisnorbiotin, and biotin-d,l-sulfoxide were approximately 10-fold greater in bile than in serum of pigs, the bile-to-serum ratios of biotin and metabolites were more than 10-fold less than those of bilirubin, which is actively excreted in bile.

How To Boost Your Metabolism

How To Boost Your Metabolism

In The Next 45 Minutes You're Going To Discover How To Boost Your Metabolism And Lose Weight. Who Else Wants To Boost Their Metabolism And Shed Pounds Fast?

Get My Free Ebook


Post a comment