Bile Acid Synthesis

The results from numerous sterol balance studies carried out in subjects fed diets low or high in cholesterol indicate that in humans, dietary cholesterol has little effect on fecal bile acid excretion rates. This finding is in striking contrast to results from studies of some rodent models that show that intake of pharmacological doses of dietary cholesterol can result in severalfold increases in bile acid synthesis and excretion. In contrast, some rodent species and nonhuman primates have little, if any, increase in bile acid excretion with increased intakes of cholesterol. Although there have been a few reports of enhanced bile acid excretion on a high-cholesterol diet in some patients, this does not appear to be a major regulatory response in humans.

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