Alanine

Alanine and glutamine are the principal amino acid substrates for hepatic gluconeogenesis and ureagen-esis. Alanine is produced in peripheral tissues in transamination processes with glutamate, branched chain amino acids, and other amino acids; following its release in the systemic circulation, alanine is predominantly taken up by the liver and to a lesser extent by the kidney. Here, alanine can be deami-nated to yield pyruvate and an amino group, which can be used for transamination processes, ureagen-esis, or can be excreted in urine. Thus, the alanine released from peripheral tissues may be converted to glucose in the liver or kidney and eventually become a substrate for peripheral (mainly muscular) glycolysis. This so-called glucose-alanine cycle may be especially relevant during metabolic stress and critical illness when the endogenous alanine release from peripheral tissues is increased. Simultaneously, alanine serves as a nitrogen carrier in this manner. Alanine is often used as the second amino acid in glutamine dipeptides that are applied to increase solubility and stability of glutamine in nutritional solutions.

The Most Important Guide On Dieting And Nutrition For 21st Century

The Most Important Guide On Dieting And Nutrition For 21st Century

A Hard Hitting, Powerhouse E-book That Is Guaranteed To Change The Way You Look At Your Health And Wellness... Forever. Everything You Know About Health And Wellness Is Going To Change, Discover How You Can Enjoy Great Health Without Going Through Extreme Workouts Or Horrendous Diets.

Get My Free Ebook


Post a comment