• Lumps or changes in the color or other features of the skin.

• Symptoms of obstruction in the digestive tract, or hoarseness.

• Bleeding from orifices such as the mouth or anus.

• Severe, recurrent, or constant headaches.

• Ulcers or sores that do not heal.

• Changes in bowel habits.

• Changes in the breasts.

• Painful, numb, or tingling nerves.

• Rapid, unexplained weight loss.

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