Polysaccharide fraction obtained from hot-water extract of Cordyceps, when injected into mice intraperitoneally, showed significant hypoglycemic activity in normal and streptozotocin-induced diabetic mice; the glucose level in plasma was reduced by the extract (68). Administration of the polysaccharide to normal mice significantly increased the activities of hepatic glucokinase, hexokinase, and glucose-6-phosphate dehydrogenase, although the glycogen content in the liver was reduced. Furthermore, the polysaccharide reduced the levels of triglyceride and cholesterol in plasma of Cordyceps-treated mice (69). Cordyceps polysaccharide also increased the activity of hepatic glucokinase and decreased the protein content of facilitative glucose transporter in rat liver, which therefore could contribute to the hypoglycemic activity (31).
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