In this sense, traditional Chinese herbal medicine (TCM) is interesting because herbs have been used to treat many complex disorders such as diabete mellitus, cancer, and others for which Western medicine may not have an appropriate diagnostic name. TCM is usually prescribed with several herbal constituents having different functions and the synergistic action exhibited by the multicomponent formula is effective for the management of many complicated diseases (8). Moreover, their therapeutic strategy is modulation of the inherent potential to recover the distorted balance of the physical condition (disease condition) by either suppressing or stimulating physiological reactions with a multifunctional-compound formula comprising several herbal components. It is also known that free-radical or reactive oxygen species (ROS) are exclusively involved in the pathogenesis of such disorders for which the Chinese herbal medicines are effectively applied. Therefore, antioxidant TCM is an attractive model for study of the antioxidant-based-compounds therapy of disorders related to oxidative stress. In this chapter, we discuss results obtained in the study of the preventive effect of Shengmai San (SMS), a traditional Chinese herbal prescription, on cerebral oxidative injury in rats.
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