The triterpenoid glycyrrhizin is anti-inflammatory and is metabolised to the aglycone glycyrrhizic acid, which inhibits 11-h-hydroxysteroid dehydrogenase, involved in corticosteroid metabolism. The aglycone inhibited N-acetyltransferase activity in human colon tumor cell lines, and inhibited the formation of DNA adducts (118). Although glycyrrhizin did not directly induce apoptosis, it enhanced Fas-mediated apoptotic body formation and DNA fragmentation in T-cell lines (119). The action of licorice root, the main source of glycyrrhizin, on cancer has been reviewed (71).
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