There is no reason to treat miliaria crystallina, as this condition is will go away on its own and does not cause unpleasant symptoms. However, miliaria rubra can be very uncomfortable and miliaria profunda may lead to heat exhaustion, so treatment of these two conditions is necessary.

Prevention and treatment of miliaria consist primarily of controlling heat and humidity so that the patient is not stimulated to sweat. This may mean treating a fever, reducing tight clothing, limiting activity, providing air conditioning, or (as a last resort) moving the patient to a cooler climate.

Topical treatments may include lotions containing calamine, boric acid, or menthol, cool wet-to-dry compresses, frequent showering with soap (although some doctors discourage excess soap), topical corticosteroids, and topical antibiotics. Topical application of anhydrous lanolin has resulted in dramatic improvement in patients with miliaria profunda. Anhydrous lanolin is believed to prevent ductal blockage, allowing sweat to flow to the skin surface. Calamine lotion provides cooling relief.

It may be possible to prevent miliaria by using oral antibiotics. Patients have also been treated with oral retinoids, vitamin A, and vitamin C with variable success. However, there have been no controlled studies to demonstrate the effectiveness of any of these treatments.

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