For many years, penicillin was the drug of choice, but in the late 1970s the bacteria became resistant; most resistant strains are in New York, California, and Florida, but resistance is seen in all states and most of Canada.

Today treatment involves two antibiotics, a shot of ceftriaxone and doxycycline pills. The pills will also cure chlamydia, which has similar symptoms to gonorrhea. Alternatively a doctor may give a single dose of cefixime. An infant born with the symptoms of gonorrhea must be hospitalized and given ceftriaxone.

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