Heredity

Sickle-cell conditions are inherited diseases. The types of hemoglobin a child produces depends on what hemoglobin genes the child inherited from both parents. Like most genes, hemoglobin genes are inherited in two sets—one from each parent. For example, if one parent has sickle-cell anemia and the other is normal, all of the children will have sickle-cell trait. If one parent has sickle-cell anemia and the other has sickle-cell trait, there is a 50 percent chance of having a baby with either sickle-cell disease or sickle-cell trait with each pregnancy. When both parents have sickle-cell trait, they have a 25 percent chance (one of four) of having a baby with sickle-cell disease with each pregnancy.

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