The sweat test, which measures the saltiness of sweat, is the most common test for CF, since excess levels of sodium and chloride suggest that the child has CF. However, this test may not work well in newborns because they do not produce enough sweat. in that case, an immunoreactive trypsino-gen blood test (IRT) may be performed to search for a specific protein called trypsinogen. Also, a small percentage of people with CF have normal sweat chloride levels. They can only be diagnosed by chemical tests for the presence of the mutated gene.

Other tests that can help diagnose CF are chest X rays, lung function tests, sputum cultures, and stool examinations.

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