Children who develop pneumonia from adenovirus may develop chronic lung disease. Very rarely, this strain of the virus has a 10 percent mortality rate. Children with weakened immune systems are at risk for developing a more severe infection from adenoviruses.

A severe complication of intestinal adenovirus is intussusception, an intestinal blockage that occurs when one part of the intestine slides over another section like a telescope. This is a medical emergency and most often occurs in infants under 1 year of age. The symptoms of intussusception may include bloody or "currant jelly" stool, vomiting, abdominal swelling, knees flexed to chest, loud cries of pain, weakness, and lethargy.

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