Clinical guidelines are recommendations on the appropriate treatment and care of patients with specific diseases and conditions. They are usually drawn up by multidisciplinary groups of experts and ought to be based on systematic reviews of the literature. Some, such as those developed by the National Institute for Health and Clinical Excellence, take account of cost-effectiveness.
A difference between the effects of different treatments judged by expert clinicians to be important for clinical or policy decisions. It is independent of statistical significance or cost-effectiveness.
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