Natural Remedies for Glaucoma

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Macular Degeneration and Cataracts

The eye is at particular risk of oxidative damage due to high oxygen concentrations, large amounts of oxidizable fatty acids in the retina, and exposure to ultraviolet rays. In Western countries, age-related macular degeneration (AMD) is the leading cause of blindness among older people. Cataracts are also widespread among the elderly and occur when the lens is unable to function properly due to the formation of opacities within the lens. These develop when proteins in the eye are damaged by photooxidation these damaged proteins build up, clump, and precipitate. It has been proposed that antioxidants may prevent cellular damage in the eye by reacting with free radicals produced during the process of light absorption. The results of intervention trials in this area have also been mixed. The Age-Related Eye Disease Study in the United States investigating the effects of combined antioxidant vitamins C (500 mg), E (400IU), and -carotene (15 mg) with and without 80 mg zinc daily for 6...

TABLE 4 Eye Disease in GCA

A retrospective study of eye disease occurring in 161 patients over a 17-year period provides a useful perspective of this complication (15). Visual manifestations occurred in about 26 of patients, and loss of vision in at least one eye occurred in about 15 (Table 4). Twenty-four patients had permanent vision loss in 92 of these, anterior ischemic optic neuritis was the cause. Central retinal artery occlusion occurred in 8.3 of patients as the cause of permanent visual loss, and occipital infarction caused by vertebral basilar stroke occurred in one patient (4.2 ). These authors noted that patients positive for HLA-DRB1 * 04 had visual manifestations more commonly than those who did not the phenotype was found in 42 of patients versus 26 of controls (15).

Principles for organizing an eye health system for the care of diabetic retinopathy

Accuracy of examination results If diabetic retinopathy is suspected after screening, a decision must be made about the overall management for a given level of diabetic retinopathy. In many developing countres, there are too few persons to provide even basic eye care to the population, let alone specialized eye care for patients with diabetes and related blindness prevention. Involving non-ophthalmic health care providers in varous aspects of eye care for patients with diabetes is a viable alternative. Appropriate follow-up intervals Significant problems have been encountered in ensurng regular follow-up of patients with diabetic retinopathy High rates of follow-up have, however, been reported with the use of vans and trained photographic readers using reference standard photographs to provide immediate feedback to patients. By directly addressing patient convenience, access and feedback, this system might serve as a model for a 'marketing' approach for patient-centred detection of...

Evaluation and improvement of eye care for patients with diabetes mellitus

In assessing approaches to improving the care system, it is important to (i) determine the purpose of the proposed system, for example, to screen for a threshold referral level of retinopathy or to provide guidance in management (ii) assess the performance of the system relative to that of the gold standard, in order to identify trade-offs (ii) assess the success and actual performance of different eye care systems in various settings and (iv) understand how patients perceive the benefits of the system. From the perspective of health policy, it should be shown that a traditional or non-traditional proposal for care offers significant benefits over the existing system, sufficient to justify any additional costs. The performance of systems for eye care for patients with diabetes, even in developed countres, leaves much to be desired. Application of a systems approach to the current systems indicates that alternatives should be explored to improve performance in every area of eye care...

Conduct International research into systemic deficiencies in health and eye care that contribute to blindness from

Improvements to increase the cost-effectiveness of eye care for diabetes patients are a global necessity. Blindness due to diabetic retinopathy occurs in part because factors important to both patients and health care providers have not been recognized or incorporated into current diabetes education, screening and treatment programmes. Systems analyses are needed in various cultures to understand better why patients with diabetic retinopathy go bind, particularly when the technical knowledge and services to prevent the condition exist. Operations research is needed for comprehensive, evidence-based characterization of the contributions of significant factors and their interactions to blindness among patients with diabetic retinopathy. Within a standardized protocol, focus group methods can give detailed insight about bind and non-blind patients with retinopathy, members of their families or social support systems and diabetes and eye care providers, including information on the actual...

Alternatives in eye care for patients with diabetes mellitus

All treatment should be consistent with uniform international standards. The International Council of Ophthalmology guidelines for diabetic retinopathy care (52) (See Annex 4.) give detailed information about the expected performance of ophthalmologists who treat diabetic retinopathy. Education can improve the performance of health care providers, including non-eye care professionals, although long-term data on persistence are lacking. Use of photographic standards might be an alternative that would also enhance the performance of all systems to detect and follow-up cases of diabetic retinopathy.

Agerelated Cataract Prevention

Age-related cataract is an important public health problem because approximately 50 of the 30-50 million cases of blindness worldwide result from leaving the condition untreated (Jacques 1999). The mechanisms that bring about a loss in transparency include oxidation, osmotic stress, and chemical adduct formation (Bunceetal 1990). Besides traditional risk factors such as diabetes, nutrient deficiency is also being considered, particularly those with antioxidant properties. Cataract was shown to be associated with riboflavin deficiency in animals in the 1930s and subsequently with deficiencies of amino acids, vitamins and some minerals (Wynn & Wynn 1996). This has been confirmed in human studies whereby lens opacities have been associated with lower levels of riboflavin, vitamins A, C and E, iron, and protein status (Leske et al 1995, Mares-Perlman et al 1995). Glutathione reductase is a key enzyme involved in lens protection. Riboflavin levels indirectly influence glutathione...

Prevention Of Cataracts

Numerous observational and prospective clinical studies have been performed to examine the effect of vitamin C alone or in combination with other antioxidants on cataract. Several epidemiological studies have identified an association between vitamin C and cataract incidence (Ferrigno et al 2005, Jacques & Chylack Jr 1991, Jacques et al 1988, Valero et al 2002) however, studies investigating whether supplementation is protective have produced mixed results (Chasan-Taber et al 1999, Chylack Jr et al 2002, Hammond & Johnson 2002, Jacques et al 1997, 2001, Kuzniarz et al 2001, Seddon et al 1994, Taylor et al 2002).

Present Understanding Of Dry Eye Disease And Implications For Therapy

Dry Eye Syndrome

A recent international workshop designed to collate and critique in an evidence-based manner the accumulated knowledge concerning dry eye disease and its treatment published a comprehensive report in 2007.1 The Dry Eye Workshop provided guidance to clinicians and researchers regarding the definition, classification, epidemiology, and research findings, and treatment guidelines for dry eye disease. The consensus definition of dry eye disease was stated to be that dry eye is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. It is accompanied by increased osmolarity of the tear film and inflammation of the ocular surface.2 This definition expands the scope of the disease to include effects on visual acuity and discomfort and damage to the ocular surface through both inflammation of the tissues and hyperosmolarity of the tear film.3 The classification...

Uveitis and Visual Impairment

About 80 to 90 of patients with uveitis are positive for ANA. ANA-positive girls presenting with oligo-articular disease below the age of two years have up to a 95 likelihood of developing chronic anterior uveitis. Uveitis can cause other forms of eye pathology such as glaucoma and cataracts. Iatrogenic cataract formation from long-term steroid use may also be troublesome in patients requiring oral corticosteroids for disease control.

Cataracts and Photoreceptors

Several micronutrients, especially those that can have antioxidant functions in living tissues, have recently been investigated in relation to possible protection against degenerative eye diseases, such as cataract. Studies in animal models have suggested, albeit indirectly, that riboflavin status may be important here, and several recent epidemiologi-cal studies, including an intervention study in one region of China, have supported the suggestion that

Management Of Dry Eye Disease

An effective strategy for the management of dry eye disease includes attention to the patient's lifestyle and specific pharmacologic intervention. The aggravating factors to dry eye and predisposition to symptoms of irritation are well known. Smoking has been identified as a risk factor.35 Such activities as prolonged reading, prolonged staring at a video display terminal, airplane flight, and the use of antihistamines or anticholinergic medications all increase symptoms by worsening tear film stability and volume.36,37 Often simple modification of these behaviors or the use of room humidifiers to increase ambient humidity helps to reduce symptoms, but rarely do such adjustments completely control symptoms. Ensuring that there is no intercurrent blepharitis or inflammation of the anterior eyelid margin is essential. Nevertheless, topical or systemic medications are necessary adequately to treat the disease. The guidelines proposed by the Delphi Panel and the Dry Eye Workshop based on...

Ophthalmic Diseases

AAV vectors may be well suited for efficient long-term treatment of ocular diseases because they efficiently and stably transduce retinal pigment epithelium and photoreceptor cells following subretinal injection (93,252-257). Retinitis pigmentosa (RP) is a group of inherited retinal degenerative diseases that lead to progressive reduction in visual field extent and impairment of visual acuity. The disease is triggered by mutations in various genes that cause degeneration and death of photoreceptors by apoptotic pathways (258). Control of angiogenesis in the retina is essential to the preservation of vision. Ocular neovascularization (NV) is a major threat to vision and a complicating feature of many eye diseases, including proliferative diabetic retinopathy, age-related macular degeneration, and retinopathy of prematurity. Regulation of vascularization in the mature retina involves a balance between endogenous positive growth factors (e.g., vascular endothelial growth factor), and...


Although a high intake of beta-carotene containing foods has been associated with the prevention of cataracts, the role of supplementation is uncertain. An assessment of dietary beta-carotene intake in a subgroup of 472 non-diabetic women, aged 53-73 years, who participated in the Nurses' Health Study found that the odds of posterior subcapsular cataracts was 72 lower in those with the highest intakes of beta-carotene who had never smoked, whereas beta-carotene intake and cataract risk were not associated in current or past smokers (Taylor et al 2002). This finding is contrasted with findings from intervention studies that have found that beta-carotene may help prevent cataracts in smokers (Christen et al 2003, 2004). Two years of beta-carotene treatment was found to have no large beneficial or harmful effect on the development of cataract in a randomised, double-masked, placebo-controlled trial of 39,876 female health professionals aged 45 years or older who participated in the...

Eye Strain

A double-blind study involving 75 patients with eye strain caused by viewing a computer screen found that GSE 300 mg daily significantly improved objective and subjective measures (Bombardelli & Morazzoni 1995). Grapeseed extract (Endotelon' ) has also been shown significantly to improve visual adaptation to and from bright light in a dual centre study involving 100 volunteers (Boissin et al 1998, Corbe et al 1988). A dose of 200 mg daily over 5 weeks was used. It has been proposed that GSE increases rhodopsin content of the retina or accelerates its regeneration after exposure to bright light.

Eye Problems

Cataracts In cataracts damage to the protein of the lens of the eye clouds the lens and impairs vision. Oxidation of the lens from exposure to the sun and other sources in the environment is partly responsible for the destruction and nothing can reverse the situation once it has developed. Nutrient deficiencies, selenium, for example, may contribute to cataract formation. Symptoms are blurred or hazy vision, seeing spots, or the feeling of a film over the eye. Vitamin C supplementation may help improve vision. Glutathione, an antioxidant, is found to be especially lacking in cataracts as well as vitamin C, vitamin E, and folic acid. Vitamin A and the carotenoids are important for eye health, lutein a carotenoid is found in the lens. Foods containing these antioxidants are fruits and vegetables, spinach and other green leafy vegetables, broccoli, asparagus, legumes, avocados, oranges, dark berries, plums, and cherries. The herb bilberry is high in antioxidants, 240 to 480 mg of extract...

What does Oxidant Stress Cause

Oxidant stress, through its effects on key biological sites and structures, is implicated in chronic noncommunicable diseases such as coronary heart disease, cancer, cataract, dementia, and stroke (Figure 4). Oxidant stress is also thought to be a key player in the aging process itself. A cause-and-effect relationship between oxidant stress and aging and disease has not been confirmed, however, and it is very unlikely that oxidant stress is the sole cause of aging and chronic degenerative disease. Nonetheless, there is evidence that oxidant stress contributes substantially to age-related physiological decline and pathological changes. Consequently, if it is accepted that oxidant stress is associated with aging and degenerative disease, then opposing oxidant stress by increasing antiox-idant defense offers a potentially effective means of delaying the deleterious effects of aging, decreasing the risk of chronic disease, and achieving functional longevity. For this reason, there has...

Safey Issues Related to Inhaled and Systemic Corticosteroids

The GINA document states that, in adults, systemic side effects rarely occur with daily doses of < 500 mg of BDP or equivalent doses of other ICSs. Higher doses of ICSs are associated with increased risk for bruising, cutaneous laxity, cataracts and glaucoma (in some studies), decreased bone mineral density and adrenal suppression. The expert committee admits that the actual clinical impact of ICS agents on osteoblastic activity and on adrenal suppression has not yet been determined (5). For this reason, specific recommendations for prevention of osteoporosis (in contrast to NAEPP) are not provided. children receiving long-term ICS. The committee also reported that long-term observational studies in children receiving ICS therapy for six years failed to show significant effects on bone mineral density or on incidence of subcapsular cataracts or glaucoma. The GINA committee could identify no evidence to support a risk of fracture in young children on ICS agents. However, most of the...

Complications And Prognosis

Uveitis has numerous complications, which often cause visual loss. Treatment of uveitis can also contribute to these complications. Glaucoma may arise from a pressure response to corticosteroid therapy cataracts may develop from long-term use of these agents. Appropriate management of these complications provides the best opportunity for avoiding adverse visual outcomes. Band keratopathy is a complication specifically associated with JRA and is treated by chelation and excimer laser (Fig. 1D). CME is the most common cause of decreased visual acuity in patients with posterior uveitis (Fig. 1E). Finally, other complications may result from systemic treatments (1,14,16). Prognosis is best in patients with anterior uveitis. In one study, 4 of patients with anterior uveitis lost at least 25 of visual acuity, while 43 and 40 of patients with posterior uveitis and panuveitis, respectively, developed this complication (2).

CoGans Syndrome Introductiondefinition

The principal features of CS are interstitial keratitis (IK) and vestibuloauditory neuronitis. This syndrome was reported in 1945 by David Cogan, an ophthalmologist at the Harvard Medical School, who meticulously described the medical history and findings of four patients with recurrent nonsyphilitic IK and Meniere's-like vestibuloauditory symptoms. The ocular component of CS subsequently expanded to include other types of eye

Hydrocarbon Carotenoid bCarotene

Carotenoid Cardiovascular disease Cataract Macular degeneration Lung cancer Prostate cancer Carotenoid Cardiovascular disease Cataract Macular degeneration Lung cancer Prostate cancer Excellent food sources of fi-carotene include carrots, winter squash, red-orange sweet potato, and various types of dark green leafy vegetables. No deficiency or toxicity has been observed from dietary fi-carotene intake, although very rarely high intakes can be associated with yellow pigmentation of the skin as carotenoids are stored in adipose tissue. Supplements containing fi-carotene are common. In the Women's Health Initiative, the largest observational intervention study in postmenopausal women to date, approximately 50 reported using a supplement containing fi-carotene. This trial included both a clinical trial and observational study involving more than 160 000 women. The Physicians' Health Study II also included fi-carotene as one of its interventions to determine the balance of risks and...

The Effect of Experience on Brain Development

One way that experience affects brain development is by determining which synapses are retained during the process of synapse elimination. Useful synapses are kept, while surplus ones are lost. This type of learning through selective synapse elimination is thought to happen only at certain points in development. This means that there are some types of learning that may only occur during certain points in development, sometimes called sensitive or critical periods. If certain synaptic connections are not laid down early in life, they are less likely to become established later in life. For example, some children are born with cataracts (a clouding of the lens that prevents patterned light from reaching the eye's receptor cells) and experience visual deprivation during the first months of life until the cataracts are treated. These children, even when tested years after vision has been restored, show some difficulties in face recognition, according to a study by Daphne Maurer and her...

Can I go blind with MS

Although visual loss accompanying attacks of MS, diagnosed as optic neuritis or retrobulbar neuritis, may occasionally be severe, blindness is unusual. There may be a small blind spot left after an attack, and occasionally, this may be large enough to interfere with vision. Glaucoma, which is another type of eye disease, unrelated to MS, is more common as a cause of blindness in MS patients. My vision problems range from a bit of blurriness to a complete lack of sight. I inherited extreme myopia I wear contact lenses and glasses even in the shower. Before MS, changes in my vision required new prescriptions and picking out the least offensiveframes. MS vision symptoms and Myopia nearsightedness inability to see distant objects without corrective lenses.

Micronutrient Deficiency

Cataract clouding of the lens of the eye Vitamin A. Vitamin A is necessary to develop a strong immune system and proper eyesight. Vitamin A deficiency (VAD) not only causes blindness and visual impairment (e.g., cataract), but also growth retardation and susceptibility to infections. When VAD is not detected early, it may make a child more prone to illness and even death. In Asia alone, it is estimated that 125 million children under five years of age are currently at risk, and 1.3 million are reported to be vitamin A deficient.

Neurological Effects

Reduced visual acuity, poor neurodevelopment and ill effects on behaviour. Breast-fed infants generally receive sufficient DHA if the maternal diet is adequate, but it is not known whether formula-fed infants receive adequate amounts if their formula does not contain PUFAs.

Historical Cultivation And Usage

Abrus precatorius plants are seen growing wild throughout all tropical forests, and are propagated through seeds. Traditionally the seeds were used for decorative and gold-weighing purposes. The plant is used in traditional herbal formulations to treat many ailments, mainly scratches, sores, and wounds caused by dogs, cats, and mice. In addition, it is also used to treat leucoderma, tetanus, and rabies (Chopra et al., 1956). The dry seeds are powdered and taken one teaspoonful once a day for 2 days to cure worm infections. Various African and Indian tribes use the powdered seeds as oral contraceptives. They have also been used against chronic eye diseases, and particularly against trachoma (Acharya, 2004). As well as the seeds, the leaves and roots of the plants are also used for medicinal purposes.

Clinical Manifestations

In the head and neck, atypical manifestations of CSD appear in up to 14 of patients, specifically Parinaud's oculoglandular syndrome (6 ), encephalopathy (2 ), and osteomyelitis (0.3 ) other atypical manifestations are hepatic granulomas (0.3 ) and pulmonary disease (0.2 ) (7). In general, these complications resolve without sequelae. Parinaud's oculoglandular syndrome is manifested by conjunctival granuloma, periauricular lymphadenopathy, and nonsuppurative conjunctivitis. Encephalopathy, manifested as fever and coma that progress to convulsions, may last for days to weeks cerebrospinal fluid is unremarkable. Other atypical presentations may commence with arthritis, synovitis, thrombocytopenic purpura, or erythema nodosum. Optic neuritis with transient blindness may also occur. Specifically, neuroretinitis manifests as fairly sudden loss of visual acuity, usually unilaterally, sometimes preceded by an influenza-like syndrome or development of unilateral lymphadenopathy. The most...

Other Physiological Effects

The extremely low rate of CHD in countries with high consumption of olive oil, for instance, suggests the benefits of substituting this fat for other fats. This kind of analysis has been expanded further by noting that MUFA intake is inversely associated with total mortality as well as with CHD. Some effects may well be because of the amount of anti-oxidant vitamins olive oil contains. Vegetable oils are the most important source of a-tocopherol in most diets, and olive oil contains about 12mgper100g. Evidence indicates that a-toco-pherol functions as a free-radical scavenger to protect cellular membranes from oxidative destruction. Oxidative stress has been linked to an increased risk of many chronic diseases, including atherosclerosis, cancer, and inflammatory disorders. Other injuries such as cataract and reperfusion injury are also associated with an increase in oxidative stress and a decrease in antioxidant activity. A large body of evidence suggests a beneficial effect of MUFA...

Future Work Conclusions and Recommendations

Today, more is known about the mechanisms and functions of n-3 fatty acids than other fatty acids. It is evident that Western diets are relatively deficient in n-3 fatty acids and that they contain much higher amounts of n-6 fatty acids than ever before in the evolution of human beings. Research has shown that DHA is essential for the development of the premature infant relative to visual acuity, visual function, and maturation. In the full-term infant, DHA may influence visual acuity and neural pathways associated with the developmental progression of language acquisition. These findings have led to the inclusion of DHA and AA in infant formulas in most countries around the world.

Evaluate use by health care workers of standardized reference photographs and direct ophthalmoscopy as a lowcost

As noted in section 5, this approach, involving general health care workers, probably offers an acceptable level of performance, as observed in other areas of eye care delivery (e.g. trachoma). Demonstrating that this is the case will be essential to its widespread adoption and acceptance by the societies and populations that might benefit most from such services. This information will also be necessary to provide the basis for informed decisions about trade-offs between cost and performance.

Growth and Neural Development

Recent large, randomized trials did not find differences in visual evoked potential, visual acuity, or tests of mental and psychomotor development through at least the first 18 months in term infants fed formulas supplemented with DHA or DHA plus arachidonic acid (Auestad et al., 1997, 2001 Lucas et al., 1999 Scott et al., 1998). These studies used formulas with at least 1.1 percent a-linolenic acid and had linoleic a-linolenic acid ratios close to 10 1. In the study by Scott and coworkers (1998), indices of early vocabulary development were lower in infants fed formula with DHA, but not in those fed formulas lacking DHA and arachidonic acid or containing both DHA and arachidonic acid. Birch and coworkers (1998, 2000) reported better visual evoked potential, but not visual acuity, and higher Bayley mental developmental indices scores in infants fed formulas with DHA or DHA plus arachidonic acid than in infants fed standard formula. Carlson and coworkers (1996a) on the other hand,...

Fat Absorption and Aging

Visual acuity 2, 4, 6, 9, 12 mo Visual acuity 2, 4, 6, 9, 12 mo Visual acuity 6, 17, 26, 52 wk visual acuity than infants fed Sweep VEP acuity better in infants fed supplemented formulas than in infants fed standard formula at 6, 17, and 52 wk, but not 26 wk Visual acuity not different between groups

Marian W Fischman

METHANOL Methanol is the simplest alcohol, containing only one carbon atom, four hydrogen atoms, and one oxygen atom (CH3OH). It is also called methyl alcohol, WOOD ALCOHOL, carbinol, wood naphtha, wood spirit, pyroxylic spirit, and pyroligneous alcohol or spirit. It is a flammable, potentially toxic, mobile liquid, used as an industrial solvent, in antifreeze, and in chemical manufacture. Ingestion may result in severe acido-sis, visual impairment, and other effects on the central nervous system. Methanol does not produce significant inebriation unless a very large amount is consumed.

Macular Pigment Development

Generally accepted that macular pigment density decreases with age however, there are conflicting results. In one prospective, observational study involving 390 patients, macular pigment density was not found to change significantly with age, even when elderly subjects with cataracts and ARMD were considered (Ciulla & Hammond 2004). Other studies, however, have found that macular pigment does indeed decline with age in both normal eyes (Beatty et al 2001, Bernstein et al 2002) and those with ARMD (Bernstein et al 2002) and Stargardt macular dystrophy (Zhao et al 2003), but not in retinitis pigmentosa or choroideremia (Zhao et al 2003).

Agerelated Macular Degeneration

Recent studies have produced encouraging results for people with pre-existing ARMD. Improvements of up to 92 in visual acuity tests were observed when subjects consumed a diet designed to contain approximately 1 50 g of spinach 4-7 times a week (Richer 1999), and in 30 patients with early ARMD and visual acuity of 6 9 or better daily supplementation with lutein, vitamin E and nicotinamide for 180 days improved macular function (Falsini et al 2003). The results from the Lutein Antioxidant Supplementation Trial provide further support for lutein supplementation in ARMD (Richer et al 2004). This was a double-blind, randomised, placebo-controlled study involving 90 subjects with atrophic ARMD who were given 10 mg lutein, 10 mg lutein plus broad spectrum antioxidants vitamins minerals, or placebo Lutein and Zeaxanthin 812 examined for changes in macular pigment density (MPD), photostress recovery, contrast sensitivity, and visual acuity. Both the lutein and lutein + antioxidant groups...

Applications To Health Promotion And Disease Prevention

Herbal eye-drop preparations made from Emblica officinalis, Carum copticum, Terminalia bellerica, Curcumalonga, Ocimum sanctum, Cinnamomum camphora, Rosa damascene, and meldespumapum have been used in ophthalmic disorders, namely conjunctivitis, conjunctivitis xerosis, degenerative conditions, and following cataract surgery. It was found to have a useful role in infective, inflammatory, and degenerative ophthalmic disorders (Mitra et al., 2000).

Reducing Risk Of Macular Degeneration

Lycopene supplements are sometimes used to reduce the risk of developing macular degeneration and generally support eye health. In general, It Is taken In combination with other carotenoids, such as zeaxanthin and lutein, for this indication for which there is supportive evidence (Cardinault et al 2005). Few studies are available to determine whether lycopene as a sole agent exerts clinically significant protective effects. One cohort study of 1 59 older people found no inverse association between lycopene intake and 5-year incidence of early age-related macular degeneration (ARMD) (Flood et al 2002). Alternatively, a recent study comparing 34 patients with ARMD to 21 control subjects found that of the serum carotenoid concentrations measured, only lycopene was decreased significantly in the serum LDLand HDL fractions (P< 0.05).

The Rebirth of the Laboratory School Challenge and Opportunity

Problems that are worthy of attention and study. While educators are the classroom experts, researchers offer expertise in identifying reliable strategies for testing ideas. In turn, administrators and policy makers create the guidelines to support research and classroom practice identified as best practices. To that end, the MBE Research Schools Network (RSN) is a practical infrastructure for making the goals, concerns and constraints of all parties transparent. To develop this partnership, we set out to meet four objectives a) develop a clear vision b) build trusting relationships c) set a standard for rigorous research and scholarship and d) promote meaningful assessment tools.

Nonophthalmic health professionals

Having to see yet another doctor (an ophthalmologist) presents an additional burden (59). Thus, being able to see just one doctor for comprehensive diabetes care enhances the continuity of care and thus the ability to receive higher quality care. General practitioners are usually best paced to situate the risk for vision loss for each patent as part of the overall care strategy for diabetes, as the known rsk factors for retinopathy are among the conditions managed by the general practitioner or endocrinologist. Awh, Coupes & Javitt (66) conducted pre- and post-educational assessments of 10 university-affiliated physicians (five in family practice, three internists and two endodcrmologists), who examined 20 patients. In the pre-test, 80 found that pupil dilatation for direct ophthalmoscopy was both unfamiliar and uncomfortable, and only one physician could name a medication used for dilatation. The mean score on a written examination on eye conditions and diabetes was 49 30 were...

Poison Control Centers

When a sharp line needs to be drawn between legalization and prohibition, it is useful to say that a drug is legal if it is legal for that substance to be produced and distributed for unsupervised consumption by a significant portion of the population (e.g., all adults). By this definition making marijuana available for medical use is not legalization if prescriptions are restricted to those experiencing specific, medically-diagnosed conditions (glaucoma), but it would be if any adult could write his or her own prescription. Likewise by this definition the Netherlands has legalized retail production, distribution, and use of marijuana, although wholesale (large-volume) marijuana production and distribution is still prohibited. Most other drugs in most countries are either clearly legal or clearly prohibited by this definition.

Allergic rhinosinusitis

A more effective approach to nasal congestion and inflammation is the use of a topical nasal corticosteroid spray. This class of agent is the most potent and effective modality for the treatment of allergic rhinitis and is effective against all of the manifestations of this disorder (8). Common side effects include local nasal irritation and occasional thrush. Less common, but possibly important in the case of long-term use, are an increase in incidence of glaucoma, cataracts, and osteoporosis. These drugs diminish the inflammatory influx of cells into the nasal mucosa and diminish the strength of the local allergic response.

Technical issues in the use of standard photographic images

In 2004, the American Academy of Ophthalmology concluded that, in the United States, single-field photography is adequate for screening for the purpose of detecting diabetic retinopathy but not for management (73) What is 'acceptable' necessarily varies from society to society in relation to the acceptable 'error' or 'miss' rates and the associated costs of achieving specific performance levels. Most studies indicate that performance levels with photographic systems are at least as good as or better than those of examinations by physicians and health care providers other than experienced retina specialists (75). Sufficient evidence therefore exsts that different societies and countres can adopt different technical performance standards and thus use different techniques. Some will want to do everything possible to avoid misclassification and thus use dilated seven-field photography, while others will adopt the seemingly opposite approach of using a single-field photograph through an...

Hazard Identification

Studies on the effects of L-histidine on taste and smell acuity in humans have produced conflicting results. Henkin and coworkers (1975) reported decreased taste and smell acuity in six patients given 8 to 65 g of histidine d for up to 24 days. In view of the increased urinary excretion of zinc and a decreased concentration of serum zinc, the authors postulated that the effects of histidine administration were due to a zinc-deficient state. In a study of eight healthy men given 4 g d of histidine for 2 weeks, no effects on smell or taste acuity were reported (Schechter and Prakash, 1979). Similarly, Geliebter and coworkers (1981) failed to find any effect of L-histidine on taste and smell after oral dosing of L-histidine between 24 and 64 g d for 4 weeks. Even at the lower dose (4 g d), adverse effects such as headaches, weakness, drowsiness, and nausea were reported, while at the highest doses (24 and 64 g d) anorexia, painful sensations in the eyes, and changes in visual acuity were...

NickE Goeders Revised by Nicholas DeMartinis

Culturally approved non-medical psychoactive drugs include alcohol, nicotine (tobacco), and caffeine. Psychoactive drugs that have been determined to have a high potential for harm and little medical benefit include heroin, hallucinogens, and some older sedative-hypnotics such as methaqualone. Marijuana has traditionally been placed in this category, but recent research has demonstrated potential effectiveness for medical problems including glaucoma, nausea, and weight loss associated with cancer or AIDS.

Safety Concerns Regarding Cardivascular Gene Therapy

It is theoretically possible that VEGF may exacerbate pro-liferative and or hemorrhagic retinopathy in patients with diabetes in view of the high VEGF levels demonstrated in the ocular fluid of patients with active proliferative retinopathy leading to loss of vision (109). To date, this adverse effect of therapeutic angiogenesis has not been observed. The local delivery of naked plasmid DNA encoding for VEGF-1 or VEGF-2 to more than 100 patients (one-third with diabetes and remote retinopathy) treated at our institution with up to 4-year follow-up did not effect the visual acuity or fundoscopic findings as evidenced by serial funduscopic examinations pre-and post gene transfer by an independent group of retinal specialists.

Dietary Guidelines for Health Function and Disease Prevention

The additional susceptibility of older persons to chronic degenerative diseases makes adherence to these healthful dietary patterns, throughout the periods in the life span preceding the older years, more relevant. Recent epidemiological research has shown that compliance or behavior concordant with healthy eating guidelines are associated with lower later life incidences of certain cancers, cataracts, diabetes, hypertension, stroke, and cardiovascular diseases, as well as overall survival. There is intense interest in whether and how diet and nutrition influence the maintenance of cognitive function with aging.

Laser Optical Coherence Tomography LOCT

LOCT is a noninvasive, noncontact imaging technique that produces highresolution longitudinal cross-sectional tomographs of ocular structures in real time, consequently facilitating more precise diagnoses. LOCT has been well documented as an imaging diagnosis in the early detection of glaucoma.22,23 It is also a valuable technique in the evaluation and treatment of patients with retinal disease,24,25 particularly certain macular abnormalities such as cysts, holes, pseudoholes, and puckering. Before LOCT, more limited tools (i.e., clinical examination and fluorescence angiography) were available to evaluate During the routine LCD selection process in 2003, the medical policy team weighed the options of combining individual state-specific policies on LOCT and policy retirement, because contractors need to periodically review existing LCDs to determine whether they are achieving their objectives of high-quality adjudication of claims. After consultations with both general...

Principles in assessing methods of care

Secondly for evaluation, the performance of the system relative to that of the gold standard must be known, so that the trade-offs can be identified. In the case of diabetic retinopathy the practice guidelines of the International Council of Ophthalmology (52) and the American Academy of Ophthalmology (50) prescrbe observation by a trained, experienced observer or a full seven-field photographic interpretation according to the standards of the Wisconsin Reading Center as the gold standard. Thus, any study of the value of a system, such as remote telemedicine care in diabetic retinopathy, must establish its performance and reliability relative to either of these gold standards. Nevertheless, no system is perfect at the outset. I a new approach offers added advantages, such as better access to care, reaching more people with diabetes at a lower unit cost, then a level of technical performance that is at least as good as (or perhaps lower than) current care even i not up to the gold...

The Lamp of Your Body

Does bright light bother your eyes Eat less sugar and eat more cucumbers. Trouble driving at night Eat more carrots. Are your eyes dry Potassium will help. Are cataracts blurring your vision Have your calcium and phosphorus level checked by your healthcare provider. The ratio should be ten parts calcium to four parts phosphorous. An imbalance with excessive calcium may result in a cloudy lens. We encourage eating grains and protein to lower the calcium. Eat whole foods.

Eyes Windows to the Soul

Are you bothered by spots or floaters in front of your eyes Commonly called vitreous floaters, these annoying events are often self-correcting by adding one organic carrot, raw or grated, on your mixed green salad. overworked and stressed livers are the storage house of the fat soluble vitamin A that is critical for proper eye health. Minimize toxic foods and beverages that promote liver stress. Have your healthcare physician rule out any other cause for peace of mind. And then enjoy your new level of health.

Improvement Knowledge

The health care system has an aim to improve the health of the patients it serves. This care is made through several processes, such as diagnostic services, assessments, plans of care, and delivery of care at the ward or in the clinic. All these processes include many steps that need to be analyzed and understood in greater detail before we plan to change and redesign processes for improved performance and outcomes. The clinical microsystems are the essential building blocks of the larger health care systems. The microsystem is the local context where patients and families, health care teams, support staff, information, and processes meet to provide care for a particular group of patients. In a pediatric hospital there are many microsystems, such as allergy, rheumatology, and diabetes clinics, neonatal intensive care units, and units for infectious disease. These different microsystems will interact horizontally with each other in planned and unplanned ways. A rheumatology patient,...

Visual Anatomy and Physiology

The visual field is represented in an orderly manner along the surface extent of the striate cortex with more space allocated for central than for peripheral vision. Each cell in the striate cortex is sensitive to a relatively small region of the visual field, the receptive field area of the cell. By virtue of elaborate excitatory and inhibitory connections, the input from the lateral geniculate nucleus is reorganized are common. Each cell discharges optimally when an eye movement of a certain direction and amplitude is executed each region in the colliculus represents different directions and amplitudes of eye movements arranged in an orderly fashion. Electrical stimulation elicits saccadic eye movements with very low currents. The superior colliculus plays a central role in the generation of saccadic eye movements. However, several other structures, including regions in the occipital and parietal lobes, the frontal eye fields, and the medial eye fields in the frontal lobe also...

Localized Scleroderma

(with loss of hair from the scalp and eyebrows), ptosis, uveitis, cataract, keratopathy, and seizures may occur (95,96). Atrophy of the tongue and abnormal or stunted growth of the teeth can be seen (95,96). Intracerebral calcification and white-matter changes have been identified on imaging (95,98).

Biosynthesis Of Betanin

Prickly pear has long been known in traditional medicine for treating a number of pathologies from ulcer, fatigue, and dyspnea to glaucoma, liver conditions, and wounds (11,13). Studies with different models and several experimental conditions provided some scientific basis for the popular use of this plant. Various preparations from fleshy stems (cladodes) have been tested for treatment of diabetes symptomatology in animal models (14,15), or in humans (16). The mechanism for this action is still unknown some results, however, preclude a role for dietary fiber (15). Other studies revealed beneficial effects against ethanol-induced ulcer (17), in the treatment of benign prostatic hypertrophy (18,19), and in hypercholesterolemia in humans (20) and guinea pigs (21). Diuretic activity of cladode, flower, and fruit infusions has been shown in rats (22). Obviously, other investigations are required to gain insight into the active agents in this plant and the mechanisms involved in all the...

The Representation Of The Eye On The

However, the most interesting evolution in the identification of points areas related to eye disorders concerns two points reported in 1959 by Dr Xu Zuo-Lin of Beijing in the first Chinese clinical validation on ear acupuncture (see Fig. 1.11). The points were located on the posterior-lateral and anterior-internal edge of the intertragic notch and called by the author respectively astigmatism and glaucoma. The points were then placed definitely on the external border of the intertragic notch and renamed Eye 1 and 2 by the Chinese Academy of Traditional Medicine. Their common and unique indication was 'pseudomyopia', intending by this perhaps a defect in sight simulating myopia. The points were included in the standardization process and renamed as anterior and posterior intertragic points with the respective Pinyin of pingjianqian and pingjianhou. Their main indication was changed to 'ametropia' but further disorders were added too such as glaucoma and conjunctivitis. A further...

Shellfish poisoning paralytic 245

Symptoms Symptoms, which usually appear eight hours to eight days after ingestion, begin with nausea and vomiting, watery or bloody explosive diarrhea and stomach cramps, weakness, vision problems, headache, and difficulty swallowing. Those with weakened immune systems may have more serious diarrhea and may take longer to recover. Young children have more serious symptoms, and those children already malnourished or weak will be much sicker.

Disorders of Galactose Metabolism Clinical Manifestations

Classically, the term 'galactosemia' was associated with an inherited disorder of galactose utilization characterized by malnutrition, liver disease, cataracts, and mental retardation, resulting from the specific deficiency of galactose-1-phosphate uridyl-transferase. However, other enzymatic defects with variations of clinical presentation can also lead to galactosemia (Table 1). Thus it is preferably better to refer to these abnormalities of metabolism by the specific enzymatic deficiencies which are described below. Cataracts symptoms Cataracts Cataracts have been observed within a few days of birth. These may be found only on slit-lamp examination and can be missed with an ophthalmoscope, since they consist of punctate lesions in the fetal lens nucleus. Several hypotheses have been postulated to account for their formation and are mentioned above. It seems conclusive that the initiator of the process in rats is galactitol and not galactose 1-phosphate. Galactose 1-phosphate...

Cauterization Of The

Cauterize Ear

If we limit our research to ancient Europe, there are traces in folk medicine which indicate that the external ear also had some significance in the prevention of disease. One noteworthy folk tradition is the custom of wearing earrings to improve sight or to prevent eye disease. Sailors of the European coasts and mountaineers of the central Alps shared this tradition, even though contact between these two populations was exceedingly rare in previous centuries. The custom, passing from one generation to the next, was popular in the valleys of Switzerland, Austria and northern Italy, and a common saying there, even in recent times, was 'gold fits good sight', referring of course to the wearing of a gold earring.

Plantago major L Plantaginaceae Common Plantain Whitemans Foot Daun Sejumbok

Nica Granatum

Traditional Medicinal Uses The Greeks and Romans used it as an astringent, to heal wounds, asthma, fever and eye disorders. 5 In Brazil, it has been used to treat skin ulceration (cutaneous leishmaniasis) caused by Leishmania braziliensis. 6 P. major has been used in Turkey in the treatment of ulcers by taking the powdered dried leaves together with honey daily before breakfast. 7 Infusion of the leaf has been taken for diarrhoea, ulcers, bloody urine, digestive disorders, and excess mucous discharge. The American Indian groups make use of a poultice of the leaves for pain, swelling, cuts, wounds, sores, infections, blisters, insect bites, snakebites and haemorrhoids. 5 Its seeds are used to induce sweating, increase flow of urine, treat diarrhoea, dysentery, rheumatism, malaria, asthma, kidney problems, bladder diseases, gonorrhoea and piles. 3 Its roots are used to treat fever, respiratory infections and constipation. 5 The Commision E approved the internal use of plantain for...

What and where systems

The other half of the double dissociation consists of some patients with visual agnosia (see Chapter 4). This is a condition in which there are severe problems with object recognition. DF is the most studied patient having visual agnosia coupled with fairly good spatial perception. In spite of having reasonable visual acuity, DF was unable to identify any of a series of a selection of drawings of common objects. However, as was pointed out by Milner, Carey, and Harvey (1991), DF had little difficulty in everyday activity such as opening doors, shaking hands, walking around furniture, and eating meals. she could accurately reach out and grasp a pencil orientated at different angles.

Allergic Conditions On The Auricle

Auricular Acupuncture

As regards the specific areas representing the end organs of an allergic reaction, it may be noticed that patients with seasonal rhinoconjuncti-vitis due to grass pollen, besides the Shen men area, show two further areas tender to pressure (Fig. 5.30A). The first is an area presumably representing the liver we know about the importance given by TCM to the Liver meridian for treating eye dysfunctions. Another sensitized area is that around the intertragic notch which in my opinion represents the end organ eye-nose of the allergic reaction. According to the Chinese, the anterior and posterior intertragal notches hold indications related to the eye, for example glaucoma and conjunctivitis, but the representation of the nose below the intertragic notch has never been reported by the main schools (see also below).

Phyllanthus amarus Schum Thonn

Phyllanthus Amarus

Traditional Medicinal Uses The aerial part of the plant is used for various conditions. In Chinese medicine, the plant is made into a tea to cure kidney problems, venereal diseases, stones in the kidneys and bladder. The Malays use it to increase menstrual flow, reduce fever and cure colic. It is used by the Indians as a fish poison. 5 Indians also use the plant as liver tonic to treat liver ailments, ascites, j aundice, diarrhoea, dysentery, intermittent fever, conditions of the urogenital tract, eye disease, scabies, ulcers and wounds. 12 In Vietnam, it is used to induce sweating, and increase menstrual flow. It is also prescribed for toothache, muscle spasms and gonorrhoea. It is considered a diuretic, colic remedy and abortifacient in Southeast Asia. 5 It is also commonly used in Benin, Africa, as folk medicine against malaria. 13

Promotion Of Remineralization And Reversal Of The Demineralization Process

Sjogren Wound

Increasing the amount of saliva in the mouth may be achieved in those individuals who have functioning salivary glands by means of the use of sugar-free hard candies or lozenges (Salive), sugar-free chewing gum, or by the use of a muscarinic agonist. A xylitol- containing gum or candy may have additional clinical benefit (Xylichew, Spry, TheraGum,). Pilocarpine tablets, Cevimeline capsules, or Bethanachol may be prescribed to increase saliva production. These medications are contraindicated in those who are pregnant or have a history of uncontrolled asthma, gastrointestinal ulcer, acute iritis or narrow angle glaucoma, and they may not be suitable for those who have unstable cardiovascular disease. Some individuals decide to discontinue the prescribed muscarinic agonist because of intolerable adverse effects, including sweating. In these cases, it is possible to titrate the medication (ie, pilocarpine, by cutting the 5 mg or 7.5 mg pill to a final dose of 2.5 to 3.75 mg three times...

Confidence And Appearance Stereotypes

Self-perception theory asserts that we know our own attributes in the same way that we know about the attributes of others. If that is the case, then stereotypes about appearance that affect our judgments of others should affect our judgments of ourselves as well. Certainly stereotypes are powerful determinants of our judgments of others. For example, more attractive people are routinely judged to be smarter and more humorous and to have performed better at a variety of tasks (Dion, Berscheid, & Walster, 1972). Tall people are more likely to be seen as leaders conversely, people who have achieved leadership positions are judged to be taller than they actually are (Jackson & Ervin, 1992 Montepare, 1995 Wilson, 1968). Unfortunately for experimental design purposes, most stereotypical aspects of appearance, such as attractiveness or height, are not easily manipulated. Fortunately, one is. This is the stereotype that people who wear glasses are more intelligent....

Indications Caper Bush

Adenopathy (f BIB JLH) Aging (f BIB) Allergy (1 X15799005) Amenorrhea (f DEP) Arteriosclerosis (f BIB BOU) Arthrosis (f BIB) Bleeding (f BOW) Cancer (f1 BIB) Cancer, abdomen (f1 FNF JLH) Cancer, bladder (f1 FNF JLH) Cancer, colon (f1 FNF JLH) Cancer, groin (f1 FNF JLH) Cancer, head (f1 FNF JLH) Cancer, kidney (f1 FNF JLH) Cancer, liver (f1 FNF JLH) Cancer, neck (f1 FNF JLH) Cancer, spleen (f1 FNF JLH) Cancer, uterus (f1 FNF JLH) Cataract (f BIB) Chill (f BIB BOU) Cirrhosis (f WO2) Cold (f BIB) Conjunctivosis (f BOW) Cough (f BOW GHA) Cramp (1 HOS) Cystosis (f JLH) Dengue (f BIB HJP) Diabetes (f GHA) Diarrhea (f BOW BOU) Dropsy (f BIB BOU DEP) Dysentery (f BIB) Dysmenorrhea (f BIB) Earache (f BI2 GHA) Enterosis (f BOW) Erythema (1 X15799005) Fever (f BOU) Fracture (f BIB) Ganglion (f BOU) Gastrosis (f BOW GHA) Gout (f DEP SKJ WO2) Headache (f BIB) Hepatosis (f1 JLH HOS WO2) Hyperacidity (f MKK) Impotence (f BOU) Induration (f JLH) Infection (f BOW BOU) Infertility (f BIB BOU)...

Xanthophylls Lutein and Zeaxanthin

Free radical damage is also linked to the development of cataracts. Cataracts remain the leading cause of visual disability in the US and about one-half of the 30-50 million cases of blindness throughout the world. Although cataracts are treatable, blindness occurs because individuals have either chosen not to correct the disease or do not have access to the appropriate medical treatment. Several epidemiological studies have shown inverse associations between the risk of cataracts and carotenoid intake. However, these studies also present inconsistencies with regard to the different carotenoids and their association with cataract risk. Lutein and zea-xanthin are found in the lens and are thought to protect cells in the eye against oxidative damage, and consequently prevent formation of cataracts. However, to date, there is no evidence that any carotenoid supplement can protect against cataract development. Eating plenty of fruits and vegetables, good sources of many antioxidants...

Biochemistry and Physiology of Galactose

The main pathway of galactose metabolism in humans is the conversion of galactose to glucose, without disruption of the carbon skeleton. The name 'galactosemia' has been associated with a syndrome of toxicity associated with the administration of galactose to patients with an inherited disorder of galactose utilization, leading to multiple clinical manifestations, including malnutrition, mental retardation, liver disease, and cataracts. The clinical manifestations are linked to specific enzymatic defects. Thus the term 'galactosemia' should be qualified by the specific defect. Three enzymatic steps are required to metabolize galactose to UDP-glucose. Two alternate pathways, oxidation and reduction, are used in the absence of enzymes of the main route. Patients with classical galactosemia have markedly elevated levels of galactitol in plasma and urine, which remain above age-matched control levels after treatment with galactose-free diet, whereas high urinary galactose levels return to...

Think I am a good candidate for gastric bypass surgery What do I need to do to obtain insurance coverage for this

Ship with your primary care doctor, he or she will know about your weight loss attempts and will be treating you for any of your obesity-related illnesses or conditions (elevated cholesterol and triglycerides, gallstones, pancreatitis, abdominal hernia, fatty liver, diabetes or prediabetes, polycystic ovary syndrome, high blood pressure, heart disease, pulmonary hypertension, stroke, blood clots in the legs and lungs, sleep apnea, arthritis, gout, lower back pain, infertility, urinary incontinence, or cataracts).

Integration of information

Tovee (1996) raises various problems with oscillation-binding theory. Oscillation only seems to occur with moving stimuli, and so the theory cannot apply to static stimuli. In addition, the evidence suggests that oscillations develop too slowly and last for too long for them to contribute to object perception. Tovee argued that there may be less of a binding problem than has sometimes been supposed. The fact that there is only high visual acuity for stimuli presented to the fovea of the retina (combined with attentional focusing) creates almost a tunnel vision effect, where only the visual information from the centre of the visual field

Streptobacillus moniliformis

Kidney inflammation (acute glomerulonephritis) is another possible complication of strep throat, which can appear from 10 days to 6 weeks after the throat infection. The bacteria do not directly infect the kidneys instead, the body's immune system response can damage the kidney's filtering mechanism. Warning signs of impending kidney problems include swelling of hands, face, and feet dark or bloody urine headaches vision problems and decreased urinary output. Children usu-

Combined Oral Contraceptives

It is unusual to have serious side effects, but if you do, call your nurse or doctor right away. These serious effects may be signalled by abdominal pain, very bad headaches, unusual pain in your legs, chest pain, eye problems like blurred vision, or difficulty breathing. Vision Problems. Double vision, loss of vision, eye pain or swelling, or discomfort while wearing contact lenses are rare side effects of the Pill. If any of these symptoms occurs, you should stop taking the Pill, use another method, and talk with your physician.

Listeria monocytogenes

Treatment Diethylcarbamazirie has been the preferred drug for the past 40 years, and usually cures the disease, and may also be useful as a preventive measure. The drug kills both worms and microfilariae. However, it should be used with caution in patients with heavy infestations of worms, since this can provoke eye problems. Antihistamines and prednisone may be needed to ease allergic reactions due to the disintegration of microfilariae.

Plate Iii Skin Alterations Related To Vascularization Paleness Hyperemia Telangiectasia

Otic Eczema

Plates IIIC and IIID Telangiectasia and spots on the lower border of the right ear lobe where two descending creases are going to meet together (C) paleness of the corresponding part of the left ear lobe (D) in a 66-year-old female affected by glaucoma and hypertensive retinopathy. Plates IIIC and IIID Telangiectasia and spots on the lower border of the right ear lobe where two descending creases are going to meet together (C) paleness of the corresponding part of the left ear lobe (D) in a 66-year-old female affected by glaucoma and hypertensive retinopathy.

Congenital Constitutive Diarrheal Disorders

Atrophy Microvilli

In IED TE, massive watery diarrhea develops within the first days after birth in a way similar to MVA MVID. Stool volumes are highly variable (100-200 ml kg body weight day) with stool electrolyte concentrations of sodium of 100-140 mmol l 6, 7 . All children are highly dependent on par-enteral nutrition. There is no past history of hydramnios or other antenatal or neonatal particularities. It is striking that in our experience most children with IED TE have consanguineous parents and or affected siblings and some of them died during the first months of life with severe diarrhea of unknown origin. Upon clinical examination, no malformations are observed however, some children have somewhat rigid hair and a subgroup of patient shows clinical signs of photophobia. Distinct ophthalmologic examination reveals the presence of superficial keratitis in these children. The degree of severity of IED TE is more variable compared to MVA MVID with most children developing a severe course...

Indications Camelthorn

Abscess (f BIB KAB) Adenopathy (f JLH UPW) Anorexia (f BIB SAY) Arthrosis (f GHA) Asthma (f BIB) Atherosclerosis (1 WO3) Bacteria (1 WO2) Biliousness (f DEP) Bleeding (f BIB) Bronchosis (f BIB) Cancer (f JLH) Cancer, abdomen (f JLH) Cancer, gland (f JLH) Cardiopathy (1 X1305866) Cataract (f GHA PAY) Catarrh (f PAY) Cerebrosis (f BIB) Constipation (f PAY) Corneosis (f BIB) Cough (f DEP PAY) Dermatosis (f BIB) Diarrhea (f1 SAY X15138016) Enterosis (f UPW) Epistaxis (f BIB) Fever (f PAY) Gastrosis (f PAY) Gingivosis (f PAY) Halitosis (f PAY) Headache (f BIB WO3) Hematachezia (f PAY) Hemicrania (f BIB KAB) Hemorrhoid (f BIB KAB) High Blood Pressure (1 WO3) High Cholesterol (1 WO3) High Triglycerides (1 WO3) Impotence (f PAY) Infection (f1 PAY WO2) Jaundice (f GHA) Leprosy (f BIB KAB) Migraine (f BIB) Nephrosis (f PAY) Obesity (f1 BIB KAB WO3) Odontosis (f PAY) Opacity (f BIB) Ophthalmia (f KAB) Pain (f1 GHA WO3 X15507342) Polyp (f JLH) Pulmonosis (f JLH PAY WO3) Rheumatism (f PAY WO2)...

Development of the Self Concept

I have br own eyes and br own hair. And I have br own eyebrows. I am nine years old. I LOVE sports. I have seven people in my family. I have gr eat eyesight and I have lots of friends. I will be 10 in September. I live at 1923 Pinecr est. I am a boy . I have an uncle that is almost 7 feet tall. My school is Pinecr est and my teacher is Mrs V . I play Hockey.

Ayervedic Medicine Dr Abel

The Chinese herb Jue-ming-zi has been used in many traditional Chinese medical prescriptions. C. tora was first recorded in Shen-Nung-Pen-Tsao-Ching as upper category, and in the successive Pen-Tsao of descending dynasties. It is used to remove ''heat'' from the liver and improve visual acuity, to moisten the supposedly dry digestive apparatus, and to facilitate bowel movement as a laxative. Previous studies on C. tora show its therapeutic effects on hypertension (7,8), on hypercholesterolemia (9,10), as an antihepatotoxin (11), an antimicrobial (12-14), on blood platelet coagulation (15), on the eyes, and in constipation (16). This herb has been reported to contain many active substances, including chrysophenol, emodin, rhein, etc. (17). Recently many researchers have studied the antioxidant activity and antigenotoxicity of C. tora. Choi et al. (18) reported that anthraquinone aglycons and naphthopyrone glycosides from C. tora had inhibitory activity against aflatoxin B1 in the Ames...

Antioxidant Properties

Spirulina has a very high content of h-carotene and is believed to owe some of its potent antioxidant activity to it (29). The total carotenes in it have been shown to have a bioavailability comparable to other sources. In two very large-scale human trials with preschool children in South India, spirulina feeding led to an increase in serum retinol levels (30) and a significant decrease in '' Bitot's spot,'' a symptom of vitamin A deficiency (31). This finding is very important in view of the prevalence of blindness and eye diseases among children of the Third World caused by vitamin A deficiency.

Neurocutaneous syndromes

Neurofibromatosis (NF) One of the most common neurocutaneous syndromes that primarily affects the growth and development of nerve cells, causing tumors or neurofibromas that produce skin changes, bone deformities, eye problems, and other complications, especially in the brain. In 1882 neurofibromatosis (NF) was first described in medical literature by Dr. Friedrich von Recklinghausen, and the disease was known as Von Recklinghausen's disease for many years. NF affects more than 100,000 Americans, making this condition more common than cystic fibrosis, hereditary muscular dystrophy, Huntington's disease, and tay-sachs disease combined.

Mucous Membrane Pemphigoid

Crack Cocaine Effects Teeth

FIGURE 31 Mucous membrane pemphigoid. Middle-aged edentulous adult female with history of stomatitis of six months duration involving the upper and lower alveolar ridges. Observe the broad, confluent, ulcerated pseudomembrane-covered zones extending from the crest of the alveolar ridge to the reflection of the labial vestibule. An ophthalmologic workup was negative for ocular mucosal disease involvement. Direct immunofluorescence findings showed IgG and C3 deposits at the basement membrane zone. Source Courtesy of Charles Dunlap, DDS. FIGURE 31 Mucous membrane pemphigoid. Middle-aged edentulous adult female with history of stomatitis of six months duration involving the upper and lower alveolar ridges. Observe the broad, confluent, ulcerated pseudomembrane-covered zones extending from the crest of the alveolar ridge to the reflection of the labial vestibule. An ophthalmologic workup was negative for ocular mucosal disease involvement. Direct immunofluorescence findings showed IgG and...

What can happen if my diabetes is not properly treated and controlled

The longer-term consequences of less than adequate diabetes control are the result of damage to the small (micro) and larger (macro) vessels of the circulation. The most common manifestations are diabetic eye disease (retinopathy), which is the leading cause of blindness in working-age adults in the United States diabetic kidney disease (nephropathy), which is the leading cause of severe kidney failure necessitating dialysis or transplantation in working-age adults in the United States and nerve damage (neuropathy), which is present in about 1 out of 3 people with diabetes at the time of diagnosis and in over 7 out of 10 by the time diabetes has been present for 10 years. Both retinopa-thy and nephropathy can be entirely without symptoms

Leukotriene Modifiers Safety Considerations

Standard asthma treatments may be complicated by several adverse effects. For instance, p-agonists may cause tachycardia, palpitations, and headaches. Theophylline has a very narrow toxic-therapeutic window, interacts with many medications, and may cause tremors, nausea, and several other ill effects. While systemic corticosteroids have a myriad of adverse effects, including hyperglycemia, growth retardation, hypertension, insomnia, and edema, even inhaled corticosteroids pose risks, including cataracts, thrush, adrenal suppression, and bone loss (162,163). In contrast, the leu-kotriene modifiers continue to have an excellent safety profile and offer the

Solanaceae Nightshade family

Lycium is both a food and a medicine, and the berries can be eaten daily, dried if fresh isn't available, with claimed improvement in strength, eyesight, and male sexual performance. They are safe even in quantity, with no reported safety issues, except when somebody has problems with nightshade family plants, such as potato or tomato. Regular use of lycium berries can help improve night vision, reduces excessive watering of the eyes, and delays the onset of cataracts and glaucoma. The berries also stimulate lubrication of dry, red, or painful eyes, and prevent macular degeneration. eyesight

Ivclinical Indications

Extract is much more recent and results from research inspired not by traditional medicine but linked instead to the development of pharmacology. A first extract was marketed in 1965 in Germany by Dr. Willmar Schwabe Company. EGb 761 was first registered in France in 1974 and sold in 1975 by Institut Ipsen (now Ipsen Pharma) under the trademark Tanakan and in Germany as Rokan by Intersan in 1978 and as Tebonin forte by Dr. Willmar Schwabe Company in 1982. Its first therapeutic indications involved circulatory disturbances. More recently, the therapeutic effects that have been studied most are those affecting the psychobehavioral disorders associated with aging. These include cognitive disturbances, such as age-related memory disorders (grouped together today as mild cognitive impairment, MCI), or dementia, such as Alzheimer's disease. Whether these various indications (Alzheimer's disease, in particular), are included in the approved indications varies from country to country. EGb 761...

Hay William Howard MD 18661940 Creator of the Hay Diet in 1911 the original inspiration for food combining

In his interest to improve national health and decrease mortality, Hay became more interested in natural medicine. He resolved, to take such things as he believed were intended by nature as foods for men after he cured himself of Bright's disease (now known as nephritis, or kidney disease) (Hay 1933 13). He also lost weight by changing his diet, and at the end of three months he was able to run long distances without distress. His weight decreased from 225 lbs. to 175 lbs years seem to fall away from him, and he felt younger and stronger than before for many years (Hay 1934 14). He accomplished this all by eating foods in their natural, unprocessed state and not eating to excess Proportion the amounts to the real desire at the time do not try to eat the whole because it is offered a mistake that is often made by those following suggested diets (Hay 1934 158). In addition, he believed that exercise is needed to keep us clean inside, and to enjoy all these periods as only one can do who...

Stevensjohnson syndrome

Stevens Syndrome Disease

The remaining interventions are similar to those of patients suffering thermal burns thermal environmental control, fluid replacement, pain control, nutritional support, and antibacterial treatment when needed. Intubation and mechanical ventilation are needed when the trachea and bronchi are involved. Anticoagulation has been recommended, because thromboembolism and disseminated intravascular coagulation (DIC) are important causes of morbidity and mortality. Aggressive management by an ophthalmologist is necessary. Mortality rates for SJS range from 5 to 10 and increase to 30 to 40 for cases of TEN. Most patients die of sepsis or pulmonary involvement. SJS and TEN can produce significant ocular sequelae, including severe visual loss in a significant number of patients, requiring intensive involvement of an ophthalmologist. Residual skin discoloration, persistent erosions of the mucous membranes, phimosis, abnormal nail regrowth, and synechiae of the genital mucosae can also occur.

Recognition of Zinc Deficiency in Developing Countries

The detection of zinc deficiency in populations and the recognition of its association with health outcomes have been somewhat more challenging for zinc than for other nutrients, contributing to the delay in efforts to control it. The ability to diagnose zinc deficiency in individuals using biochemical measures is somewhat limited. For example, the concentration of zinc in serum or plasma may not diminish until the depletion of zinc is more advanced, making it less useful for diagnosing mild to moderate zinc deficiency states in individuals. Other possible biochemical indicators of zinc status have not been consistently demonstrated to reflect change in zinc status. These limitations may have subsequently dampened enthusiasm for evaluating zinc status at the population level. Furthermore, the health conditions that are clearly associated with zinc deficiency (e.g., childhood growth stunting, common childhood infections, and mortality described in further detail below) are general in...

Applications In Health Promotion And Disease Prevention

And chemical properties of bambara groundnut. All data reported are based on ethno-botanical information obtained from local communities. In many parts ofAfrica, bambara has recognized medicinal uses. Seeds are currently used in Burkino Faso to overcome numerous human diseases (Nacoulma-Ouedraogo, 1996). In north-eastern Nigeria, the seeds are not only consumed as food, but also used for medicinal purposes (Atiku, 2000). Seeds are used by the Igbos tribe in Nigeria to treat venereal diseases, and, according to the Luo tribe in Kenya, seeds are also used to overcome diarrhea. The consumption of roasted seeds is recommended in the treatment of polymenorrhea. The cooking water of BG seeds is used as drink, as a remedy for internal bruising here, in order to speed up the resorption of hematomas, sufferers are advised to drink seed flour diluted in water. Crushed seeds mixed with water are also administered to treat cataracts.

Pigmentation disorders

This condition is caused by an inherited absence of pigmentation in the skin, hair and eyes, resulting in white hair, pink skin and eyes. The pink colour is produced by underlying blood vessels which are normally masked by pigment. Other clinical signs of this condition include poor eyesight and sensitivity to light.

Ophthalmic Conditions

Bilberry preparations have been used to improve poor night vision, light adaptation and photophobia, myopia and to prevent or retard diabetic retinopathy, macular degeneration and cataracts. Primarily the collagen-enhancing and antioxidant activities of bilberry provide a theoretical basis for these indications. Visual acuity and light adaptation A systemic review of 12 placebo-controlled trials (5 RCTs and 7 placebo-controlled non-randomised trials) concluded that the 2007 Elsevier Australia A significant improvement in visual performance has been demonstrated for bilberry extract in people with retinitis pigmentosa and hemeralopia (inability to see distinctly in bright light), suggesting that effects may be more pronounced in cases of impaired visual acuity (Gloria & Peria 1966, Junemann 1967). Glaucoma In one small study of eight patients, a single oral dose of 200 mg bilberry anthocyanosides was shown to improve glaucoma, as assessed by electroretinography (Caselli 1985)....

Indications Black Mustard

Abscess (f DAW) Adenopathy (f JLH) Ague (f DEM) Alopecia (f DAW) Ameba (f DAW) Amenorrhea (f FEL) Angina (f FEL HHB) Anorexia (f DAW DEM KAB) Apoplexy (f FEL) Arthrosis (1 FNF) Asthma (f DEM) Bite (f CEB) Bloat (f DAW) Boil (f DAW) Bronchosis (f HHB PH2) Cancer (1 FNF JLH) Cancer, colon (1 FNF JLH) Cancer, liver (1 FNF JLH) Cancer, neck (1 FNF JLH) Cancer, sinew (1 FNF JLH) Cancer, skin (1 FNF JLH) Cancer, spleen (1 FNF JLH) Cancer, throat (1 FNF JLH) Cancer, uterus (1 FNF JLH) Cancer, wrist (1 FNF JLH) Cardiopathy (f HHB PH2) Chest cold (f HJP) Cholera (f FEL) Circulosis (f PH2) Cold (f DAW DEM WIN) Congestion (f DAW FEL) Constipation (f DAW FEL) Cough (f DAW) Cramp (f DAW) CVI (f PH2) Depression (f HJP) Dermatosis (f DAW) Dropsy (f HJP) Dysentery (f DAW) Dysmenorrhea (f FEL) Dyspepsia (f CEB FEL) Ectoparasite (f DAW) Edema (f DAW) Enterosis (f FEL PH2) Epilepsy (f DAW) Fever (f BOU DAW DEM FEL HHB) Fibroid (f JLH) Fibroma (f JLH) Gastrosis (f FEL PH2 WIN) Glaucoma (f PH2) Headache...

Terpenoids And Phenolics

Marijuana has been used for more than 4000 years for the treatment of catarrh, leprosy, fever, dandruff, hemorrhoids, obesity, asthma, urinary tract infections, loss of appetite, inflammatory conditions, and cough.15 More recently, it has been used in medicine to treat patients who have glaucoma (an eye disease) and to alleviate the adverse side effects of chemotherapy used to treat patients who

Central and Peripheral Nervous System

Special senses The special senses related directly to the cranial nerves (vision, hearing, taste, and smell) experience age-related change. With respect to vision, the most typical of all biological aging changes is presbyopia, or the loss of accommodation function for the ocular lens with loss of capacity of the associated musculature. The consequence is loss of near-vision, which leads to the need for reading glasses or bifocal spectacles. A more important aging change related to the lens is the opacification that leads to cataract formation. The eye is designed to translate light energy into visual images, but the energy of light, particularly the ultraviolet fi rays of solar energy, damages ocular tissue. Thus, there is as a strong environmental component to the disarranging of the laminar stacking of the fibrillar proteins of the lens, which imparts its clear, transparent basis consumption of diets high in antioxidant vitamins has been associated with the delay in cataract...

Why cant I read anymore

If you have difficulty seeing, consult an ophthalmologist, a medical doctor who can diagnose and treat eye conditions. Remember that you are more likely to have difficulty seeing because of conditions unrelated to PD. The eye doctor will check your visual acuity for both distance (far) vision and near (reading) vision. A common condition is presbyopia where the length of your lens changes with age and in order to read you're forced to hold the paper further and further away). A second condition is cataracts, in which the lens of your eye becomes cloudy, and you think you're looking through water. A third condition is glaucoma, which results from an accumulation of fluid behind the eye. The fluid presses on the optic nerves and can, in time, lead to blindness. Pain often accompanies acute glaucoma. Chronic glaucoma is usually silent that is, you may not know you have it. Certain PD drugs, the anti-cholinergic drugs such as Artane and Cogentin, can increase eye pressure especially in...

Bibliography Of Vitamins

Beatty S, Koh H, Phil M, Henson D, and Boulton M (2000) The role of oxidative stress in the pathogenesis of age-related macular degeneration. Survey of Ophthalmology 45, 115-34. Egger SF, Huber-Spitzy V, Alzner E, Scholda C, and Vecsei VP (1999) Corneal wound healing after superficial foreign body injury vitamin A and dexpanthenol versus a calf blood extract. A randomized double-blind study. Ophthalmologica 213, 246-9.

Conceptualization Of Depression In Older Adults

Late Life Depression Elderly

Z is a 75-year-old, widowed man who suffers from macular degeneration and diabetes, which resulted in above-the-knee amputation. He lives on the second floor of a walk-up building and has difficulty leaving his apartment because of his poor eyesight, and because his prosthesis no longer fits his leg since Mr. Z's weight loss of 15 pounds in the past year. His only income is social security, with which he barely makes ends meet. Since his eyesight began to fail and his disability increased, Mr. Z has difficulty sleeping, has little energy, has trouble gaining pleasure from activities that he once enjoyed, has trouble concentrating, and feels that life is not worth living. In addition, his eldest son needed temporarily a place to stay and asked persistently to move in with Mr. Z, a situation, which in the past has led to friction. The San Francisco based Home-Delivered Meals Program referred Mr. Z to the University of California-San Francisco (UCSF) Over-60 Clinic program for...

Phenotypes of NBCe1deficient mice

A homozygous NBCel W5l6X mutation was identified in a girl with severe pRTA (blood HCO3- concentration of l0 mM), growth retardation, and the typical ocular abnormalities including band keratopathy, cataracts, and glaucoma ll . Homozygous W5l6X KI mice also presented with severe metabolic acidosis (blood HCO3- concentration of 3.9 mM), growth retardation, hyperaldosteronism, anemia and splenomegaly, and early death before weaning ll . Due to the process of nonsense-mediated decay, the expression of NBCel mRNA was halved in the heterozygous and virtually absent in the homozygous W5l6X KI mice. The NBCel activity in isolated renal proximal tubules from the homozygous KI mice was severely reduced to less than 20 of the activity in tubules from wild-type mice. The rate of bicarbonate absorption in the homozygous KI mice was also markedly reduced to less than 20 of that in wild-type mice, confirming the indispensable role of NBCel in bicarbonate absorption from renal proximal tubules....

Nutritional Modification

Cataracts, senile macular degeneration, Impairment of immune function in older humans if inadequate amounts Increased amount in the diet is associated with delayed development of various forms of cataract Protective effect against the development of lung cancer in smokers Dietary supplementation associated with a decreased risk of age-related macular degeneration Absolute or relative deficiency associated with development of a number of cancers (not breast cancer) Dietary supplementation may decrease the rate of development of atherosclerosis Dietary deficits are associated with an increased risk of cardiovascular disease

Nutritional Value of Fish and Shellfish Introductory Remarks

When included in the diet of pregnant and breastfeeding women, DHA is thought to be beneficial to infant brain (learning ability) and eye (visual acuity) development. Scientists have found that women who ate fatty fish while pregnant gave birth to children with better visual development. Babies of mothers who had significant levels of DHA in their diet while breastfeeding experienced faster-than-normal eyesight development. Preliminary research also suggests that a diet rich in omega-3 fatty acids - and in DHA in particular - may help to decrease the chance of preterm birth, thus allowing the baby more time for growth and development.

Understanding Possible Causes of Fibromyalgia

Isa was in a very bad car crash the air bag was released so explosively that powder from the air bag flew under her contact lenses and temporarily damaged her eyes. She recovered from the accident or thought she did but then Lisa began suffering from severe and widespread pain and fatigue. Her symptoms continued to baffle her doctors for several years before one of them finally diagnosed her with fibromyalgia.