Dyslipidemia Diabetes Mellitus and the Metabolic Syndrome

Given that cholesterol gallstone disease is a metabolic problem, it should correlate with lipid abnormalities, diabetes mellitus, and adiposity. Although most gallstones in the Western world consist of cholesterol, there is no definite association with hypercholesterolemia.1 Rather, a low HDL cholesterol carries an increased risk of developing stones, as does hypertriglyceridemia.

The association between diabetes mellitus and gallstones is confounded by age, obesity, and a family history of gallstones.1 The link between diabetes, obesity, and gallstones most likely comes through the metabolic syndrome. The metabolic syndrome characterizes a specific body phenotype (abdominal obesity), insulin resistance (type 2 diabetes mellitus), and dyslipidemia (hypertriglyceridemia), all risks for cardiovascular disease. Insulin resistance predisposes to cholesterol gallstone disease,28,29 suggesting that hepatic insulin resistance must somehow affect cholesterol and bile salt metabolism.

Midsection Meltdown

Midsection Meltdown

Attention, Want 6 Pack Abs? Then Read Every Word On This Page... Revealed! Follow A Proven Plan To Unveil Your Six Pack Abs Today. Download today To Discover The Simple But Sure Way To 6 Pack Abs. This powerful tool will provide you with everything you need to finally achieve your dream of shedding the tummy fat for good and revealing your six pack abs. You can make weight loss promises to yourself all day and night, but actually sticking to your goals is the hard part.

Get My Free Ebook

Post a comment