Soft tissue injuries increase the pressure in the space between the bone and fascia as a result of edema, contracture of soft tissues, and the consequential deficiency of circulation. Neighboring soft tissues such as nerves, blood vessels, and lymph vessels are adversely affected by the increased physical pressure.
Edema, hypoxia, ischemia, tissue contracture, and necrosis may follow. Clinical data show that osteo-fascial compartment syndrome (OFCS) occurs when the compartmental pressure increases to 30 mm Hg. ISDN provides considerable relief in most cases of OFCS because of its efficacy in reducing edema.
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