Inflammation, or inflammatory response, is the physiologic process of local accumulation of fluid, plasma proteins, and white blood cells that is initiated as a result of physical injury, infection, or a local immune response. Acute inflammation refers to early and often transient episodes, whereas chronic inflammation occurs when the infection persists or when there is autoimmune disease. Inflammation is a built-in survival mechanism to protect the system from foreign invasion and to promote self-healing after tissue injury. Nevertheless, inflammation may get out of control, which results in pain or injury to tissues. Clinical evidence shows that ISDN needling brings inflammation down to the normal level at which it can assist in the process of healing. It should be noted that ISDN does not suppress inflammation but brings it to normal physiologic level.

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