In this chapter, we have reviewed the treatment of comorbid depression and GAD, PTSD, and OCD. Epidemiological and clinical studies support a strong association between these conditions, yet there is generally a paucity of research regarding the treatment of these disorders when they co-occur. It is recommended that clinicians use a comprehensive and idiographic approach to assessment, followed by a case conceptualization tailored to the individual patient. Our case example illustrates how comorbidity can significantly impact treatment and the need for the clinician to be flexible and willing to modify interventions when the outcome is not optimal. Our review also suggests the need for further scientific study in the role of comorbid anxiety and depression in psychological assessment and treatment.


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