After less successful earlier sealers, findings about the application of a filled-resin sealer (Pro-seal) have been published in the literature. One in-vitro study using an acid challenge found that demineralization was significantly less with Pro-seal treatment, compared to an untreated enamel surface (Hu and Featherstone, 2005). In fact, the demineralization levels established by microhardness profiles showed that the Pro-seal group had 98% less demineralization than the control group. This study also featured a group of teeth treated with fluoride varnish. While both the Pro-seal and fluoride varnish had significantly less demineralization than the control group, the sealer had significantly less demineralization than the varnish. Furthermore, the study also found that Pro-seal can stand up to acid challenge and toothbrush abrasion in a laboratory environment. These outcomes were corroborated by another in-vitro study, that also found that the filled-resin sealer (Pro-seal) provided significantly more protection than either fluoride varnish or an unfilled resin sealer, with a 92% reduction in lesion depth compared with the controls using polarized light microscopy (Buren et al., 2008). In looking at its supposed fluoride release, one study found that Pro-seal released fluoride ions in a sustained way - with significantly decreasing amounts over a 17-week period, though this release was measured to be sub-ppm (Soliman et al., 2006). Despite some favorable results with in-vitro models, no in-vivo trials with Proseal have been published in the literature.
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