Veno-occlusive disease (VOD) is a complication in which the flow of blood through the liver becomes obstructed. Children who have had more than one transplant, previous liver problems, or past exposure to intensive chemotherapy are more at risk to develop VOD. It can occur gradually or very quickly. Symptoms of VOD include jaundice (yellowing of the skin), enlarged liver, pain in the upper right abdomen, fluid in the abdomen, unexplained weight gain, and poor response to platelet transfusions. Treatment includes fluid restriction, diuretics (such as lasix), anti-clotting medications, and removal of all but the most essential amino acids from IV nutrition (hyperalimentation).
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