Chronic myelogenous leukemia CML

CML is rare in children, accounting for less than 5 percent of all childhood leukemias. It is characterized by a very large spleen, high white count of mostly neutrophils and other types of granulocytes, and a high platelet count. Other symptoms of CML are fatigue, weakness, headaches, irritability, fevers, night sweats, and bone pain. Some children have no symptoms and the cancer is diagnosed after a routine blood test done for other reasons.

In over 90 percent of children with CML, analysis of the cells of the bone marrow shows a genetic abnormality called the Philadelphia chromosome. This chromosome contains a "translocation" or swap of genetic material involving chromosomes 9 and 22, abbreviated as t(9;22).

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