Chromosome translocations

Sometimes genetic material is exchanged between chromosomes in leukemia cells. This is called a translocation. Translocations are very common in childhood ALL, and some of these are known to affect prognosis. Examples are:

• Movement of the TEL (ETV6) gene on chromosome 12 to the AML1 (CBFA2) gene on chromosome 21. This is called the TEL-AML1 fusion and is found most often in children between the ages of 2 and 9. Children with this translocation usually have very good outcomes.

• The Philadelphia chromosome, called t(9;22), is found in approximately 3 to 4 percent of children with ALL. It is associated with a poor prognosis, especially in older children with high white blood counts and a slow response to treatment.

• Translocations involving the MLL gene are found in 6 percent of children with ALL. The most common MLL translocation is t(4;11). This occurs most often in infants with CNS disease and high white blood counts at diagnosis. The t(11;19) translocation is associated with a poor outcome in infants but a favorable outcome in older children with T-cell leukemia and this translocation.

Confident Kids

Confident Kids

Although nobody gets a parenting manual or bible in the delivery room, it is our duty as parents to try to make our kids as well rounded, happy and confident as possible. It is a lot easier to bring up great kids than it is to try and fix problems caused by bad parenting, when our kids have become adults. Our children are all individuals - they are not our property but people in their own right.

Get My Free Ebook

Post a comment