References

1. Sanford JC, Klein TM, Wolf ED, Allen N. Delivery of substances into cells and tissues using a particle bombardment process. J Particle Sci Technol 1987; 5:27.

2. Barry ME, Pinto-Gonzalez D, Orson FM, McKenzie G, Petry GR, Barry MA. Role of endogenous endonucleases and tissue site in transfection and CpG-mediated immune activation after naked DNA injection. Hum Gene Ther 1999; 10:2461.

3. Sanford JS, Smith FD, Russell JA. Optimizing the biolistic process for different biological applications. Methods Enzy-mol 1987.

4. Smith FD, Harpending PR, Sanford JC. Biolistic transformation of prokaryotes: Factors that affect biolistic transformation of very small cells. J Gen Microbiol 1992; 138:239.

5. Johnston SA, Riedy M, DeVit MJ, Sanford JC, McElligott S, Williams RS. Biolistic transformation of animal tissue. In Vitro Cell Dev Biol 1991; 27P:11.

6. Armaleo D, Ye G-N, Klein TM, Shark KB, Sanford JC, Johnston SA. Biolistic nuclear transformation of Saccharomyces cerevisiae and other fungi. Curr Genetics 1990; 17:97.

7. Sanford JC, DeVit MJ, Russell JA, Smith FD, Harpending PR, Roy MK, Johnston SA. An improved, helium-driven biolistic device. Technique 1991; 3:3.

8. McCabe DE, Swain WF, Martinell BJ, Christou P. Stable transformation of soybean (Glycine max) by particle acceleration. Biotechnology 1988; 6:923.

9. Johnston SA, Tang DC. The use of microparticle injection to introduce genes into animal cells in vitro and in vivo. Genet Eng 1993; 15:225.

10. Daniell H, Vivekananda J, Nielsen BL, Ye GN, Tewari KK, Sanford JC. Transient foreign gene expression in chloroplasts of cultured tobacco cells after biolistic delivery of chloroplast vectors. Proc Natl Acad Sci USA 1990; 87:88.

11. Johnston SA, Anziano PQ, Shark K, Sanford JC, Butow RA. Mitochondrial transformation in yeast by bombardment with microprojectiles. Science 1988; 240:1538.

12. Zelenin AV, Titomirov AV, Kolesnikov VA. Genetic transformation of mouse cultured cells with the help of high velocity mechanical DNA injection. FEBS Lett 1989; 244:65.

Yang NS, Burkholder J, Roberts B, Martinell B, McCabe D. In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment. Proc Natl Acad Sci USA 1990; 87: 9568.

Williams RS, Johnston SA, Riedy M, DeVit MJ, McElligott SG, Sanford JC. Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles. Proc Natl Acad Sci USA 1991; 88:2726.

Wolff JA, Malone RW, Williams P, Chong W, Acsadi G, Jani A, Felgner PL. Direct gene transfer into mouse muscle in vivo. Science 1990; 247:1465.

Oard JH, Paige DF, Simmonds JA, Gradziel TM. Transient gene expression in maize, rice, and wheat cells using an airgun apparatus. Plant Physiol 1990; 92:334. Tanelian DL, Barry MA, Johnston SA, Le T, Smith G. Controlled gene gun delivery and expression of DNA within the cornea. Biotechniques 1997; 23:484.

Tanelian DL, Barry MA, Johnston SA, Le T, Smith GM. Sem-aphorin III can repulse and inhibit adult sensory afferents in vivo. Nat Med 1997; 3:1398.

Johnston SA, Tang DC. The use of microparticle injection to introduce genes into mammalian cells in vitro and in vivo. Genet Eng 1993; 15:225.

Feero WG, Rosenblatt JD, Huard J, Watkins SC, Epperly M, Clemens PR, Kochanek S, Glorioso JC, Partridge TA, Hoffman EP. Viral gene delivery to skeletal muscle: Insights on maturation-dependent loss of fiber infectivity for adenovirus and herpes simplex type 1 viral vectors. Hum Gene Ther 1997; 8:371.

Ludtke JJ, Sebestyen MG, Wolff JA. The effect of cell division on the cellular dynamics of microinjected DNA and dextran. Mol Ther 2002; 5:579.

Ludtke JJ, Zhang G, Sebestyen MG, Wolff JA. A nuclear localization signal can enhance both the nuclear transport and expression of 1 kb DNA. J Cell Sci 1999; 112:2033. Dowty ME, Williams P, Zhang G, Hagstrom JE, Wolff JA. Plasmid DNA entry into postmitotic nuclei of primary rat myo-tubes. Proc Natl Acad Sci USA 1995; 92:4572. Feltquate DM, Heaney S, Webster RG, Robinson HL. Different T cell types and antibody isotypes generated by saline and gene gun DNA immunization. J Immunol 1997; 158:2278. Hui KM, Sabapathy TK, Oei AA, Chia TF. Generation of allo-reactive cytotoxic T lymphocytes by particle bombardment-mediated gene transfer. J Immunol Methods 1994; 171:147. Tang D, DeVit M, Johnston SA. Genetic immunization is a simple method for eliciting an immune response. Nature 1992; 356:152.

Forg P, von Hoegen P, Dalemans W, Schirrmacher V. Superiority of the ear pinna over muscle tissue as site for DNA vaccination. Gene Ther 1998; 5:789.

Barry MA, Barry ME, Johnston SA. Production of monoclonal antibodies by genetic immunization. Biotechniques 1994; 16: 616.

Ulmer JB, Donnelly JJ, Parker SE, Rhodes GH, Felgner PL, Dwarki VJ, Gromkowski SH, Deck RR, DeWitt CM, Friedman A, Hawe LA, Leander KR, Martinez D, Perry HC, Shiver JW, Montgomery DL, Liu MA. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 1993; 259:1745.

Robinson HL, Hunt LA, Webster RG. Protection against a lethal influenza virus challenge by immunization with a haemagglutinin-expressing plasmid DNA. Vaccine 1993; 11: 957.

Fynan EF, Webster RG, Fuller DH, Haynes JR, Santoro JC, Robinson HL. DNA vaccines: Protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc Natl Acad Sci USA 1993; 90:11478.

32. Hooper JW, Kamrud KI, Elgh F, Custer D, Schmaljohn CS. DNA vaccination with hantavirus M segment elicits neutralizing antibodies and protects against seoul virus infection. Virology 1999; 255:269.

33. Sabin AB. Oral poliovirus vaccine: History of its development and use and current challenge to eliminate poliomyelitis in the world. J Infect Dis 1985; 151:420.

34. Fuller DH, Haynes JR. A qualitative progression in HIV type 1 glycoprotein 120-specific cytotoxic cellular and humoral immune responses in mice receiving a DNA-based glycoprotein 120 vaccine. AIDS Res Hum Retroviruses 1994; 10:1433.

35. Fuller DH, Murphey-Corb M, Clements J, Barnett S, Haynes JR. Induction of immunodeficiency virus-specific immune responses in rhesus monkeys following gene gun-mediated DNA vaccination. J Med Primatol 1996; 25:236.

36. Lu S, Arthos J, Montefiori DC, Yasutomi Y, Manson K, Mustafa F, Johnson E, Santoro JC, Wissink J, Mullins JI, Haynes JR, Letvin NL, Wyand M, Robinson HL. Simian immunodeficiency virus DNA vaccine trial in macaques. J Virol 1996; 70: 3978.

37. Fuller DH, Simpson L, Cole KS, Clements JE, Panicali DL, Montelaro RC, Murphey-Corb M, Haynes JR. Gene gun-based nucleic acid immunization alone or in combination with recombinant vaccinia vectors suppresses virus burden in rhesus macaques challenged with a heterologous SIV. Immunol Cell Biol 1997; 75:389.

38. Prayaga SK, Ford MJ, Haynes JR. Manipulation of HIV-1 gp120-specific immune responses elicited via gene gun-based DNA immunization. Vaccine 1997; 15:1349.

39. Richmond JF, Mustafa F, Lu S, Santoro JC, Weng J, O'Con-nell M, Fenyo EM, Hurwitz JL, Montefiori DC, Robinson HL. Screening of HIV-1 Env glycoproteins for the ability to raise neutralizing antibody using DNA immunization and recombinant vaccinia virus boosting. Virology 1997; 230:265.

40. Fomsgaard A, Nielsen HV, Nielsen C, Johansson K, Machuca R, BruunL, Hansen J, Buus S. Comparisons of DNA-mediated immunization procedures directed against surface glycopro-teins of human immunodeficiency virus type-1 and hepatitis B virus. Apmis 1998; 106:636.

41. Bryder K, Sbai H, Nielsen HV, Corbet S, Nielsen C, Whalen RG, Fomsgaard A. Improved immunogenicity of HIV-1 epi-topes in HBsAg chimeric DNA vaccine plasmids by structural mutations of HBsAg. DNA Cell Biol 1999; 18:219.

42. Fomsgaard A. HIV-1 DNA vaccines. Immunol Lett 1999; 65: 127.

43. Hanke T, McMichael A. Pre-clinical development of a multi-CTL epitope-based DNA prime MVA boost vaccine for AIDS. Immunol Lett 1999; 66:177.

44. Hanke T, Neumann VC, Blanchard TJ, Sweeney P, Hill AV, Smith GL, McMichael A. Effective induction of HIV-specific CTL by multi-epitope using gene gun in a combined vaccination regime. Vaccine 1999; 17:589.

45. Allen TM, Vogel TU, Fuller DH, Mothe BR, Steffen S, Boy-son JE, Shipley T, Fuller J, Hanke T, Sette A, Altman JD, Moss B, McMichael AJ, Watkins DI. Induction of AIDS virus-specific CTL activity in fresh, unstimulated peripheral blood lymphocytes from rhesus macaques vaccinated with a DNA prime/modified vaccinia virus Ankara boost regimen. J Immunol 2000; 164:4968.

46. Corbet S, Vinner L, Hougaard DM, Bryder K, Nielsen HV, Nielsen C, Fomsgaard A. Construction, biological activity, and immunogenicity of synthetic envelope DNA vaccines based on a primary, CCR5-tropic, early HIV type 1 isolate (BX08)

with human codons. AIDS Res Hum Retroviruses 2000; 16: 1997.

47. Kent SJ, Cameron PU, Reece JC, Thompson PR, Purcell DF. Attenuated and wild-type HIV-1 infections and long terminal repeat-mediated gene expression from plasmids delivered by gene gun to human skin ex vivo and macaques in vivo. Virology 2001; 287:71.

48. Purcell DF, Cameron PU, Mills J, Kent S. Infectivity of wildtype and deleted proviral SIV DNA. Dev Biol (Basel) 2001; 106:395.

49. Tahtinen M, Strengell M, Collings A, Pitkanen J, Kjerrstrom A, Hakkarainen K, Peterson P, Kohleisen B, Wahren B, Ranki A, Ustav M, Krohn K. DNA vaccination in mice using HIV-1 nef, rev and tat genes in self-replicating pBN-vector. Vaccine 2001; 19:2039.

50. Singh RA, Wu L, Barry MA. Generation of genome-wide CD8 T cell responses in HLA-A*0201 transgenic mice by an HIV-1 ubiquitin expression library immunization vaccine. J Immunol 2002; 168:379.

51. Albertini MR, Emler CA, Schell K, Tans KJ, King DM, Sheehy MJ. Dual expression of human leukocyte antigen molecules and the B7-1 costimulatory molecule (CD80) on human melanoma cells after particle-mediated gene transfer. Cancer Gene Ther 1996; 3:192.

52. Lu S, Manson K, Wyand M, Robinson HL. SIV DNA vaccine trial in macaques: Post-challenge necropsy in vaccine and control groups. Vaccine 1997; 15:920.

53. Leutenegger CM, Boretti FS, Mislin CN, Flynn JN, Schroff M, Habel A, Junghans C, Koenig-Merediz SA, Sigrist B, Aub-ert A, Pedersen NC, Wittig B, Lutz H. Immunization of cats against feline immunodeficiency virus (FIV) infection by using minimalistic immunogenic defined gene expression vector vaccines expressing FIV gp140 alone or with feline in-terleukin-12 (IL-12), IL-16, or a CpG motif. J Virol 2000; 74: 10447.

54. Nakano I, Maertens G, Major ME, Vitvitski L, Dubuisson J, Fournillier A, De Martynoff G, Trepo C, Inchauspe G. Immunization with plasmid DNA encoding hepatitis C virus envelope E2 antigenic domains induces antibodies whose immune reactivity is linked to the injection mode. J Virol 1997; 71: 7101.

55. Fournillier A, Nakano I, Vitvitski L, Depla E, Vidalin O, Maer-tens G, Trepo C, Inchauspe G. Modulation of immune responses to hepatitis C virus envelope E2 protein following injection of plasmid DNA using single or combined delivery routes. Hepatology 1998; 28:237.

56. Forns X, Emerson SU, Tobin GJ, Mushahwar IK, Purcell RH, Bukh J. DNA immunization of mice and macaques with plasmids encoding hepatitis C virus envelope E2 protein expressed intracellularly and on the cell surface. Vaccine 1999; 17:1992.

57. Schirmbeck R, Konig-Merediz SA, Riedl P, Kwissa M, Sack F, Schroff M, Junghans C, Reimann J, Wittig B. Priming of immune responses to hepatitis B surface antigen with minimal DNA expression constructs modified with a nuclear localization signal peptide. J Mol Med 2001; 79:343.

58. Roy MJ, Wu MS, Barr LJ, Fuller JT, Tussey LG, Speller S, Culp J, Burkholder JK, Swain WF, Dixon RM, Widera G, Vessey R, King A, Ogg G, Gallimore A, Haynes JR, Heyden-burg-Fuller D. Induction of antigen-specific CD8 + T cells, T helper cells, and protective levels of antibody in humans by particle-mediated administration of a hepatitis B virus DNA vaccine. Vaccine 2000; 19:764.

59. Hota-Mitchell S, Clarke MW, Podesta RB, Dekaban GA. Recombinant vaccinia viruses and gene gun vectors expressing the large subunit of Schistosoma mansoni calpain used in a murine immunization-challenge model. Vaccine 1999; 17: 1338.

60. Lodmell DL, Ray NB, Ewalt LC. Gene gun particle-mediated vaccination with plasmid DNA confers protective immunity against rabies virus infection. Vaccine 1998; 16:115.

61. Chang SW, Bu J, Rompato G, Garmendia AE. A vector DNA vaccine encoding pseudorabies virus immediate early protein demonstrates partial protection in mice against lethal virus challenge. Viral Immunol 1998; 11:27.

62. Schmaljohn C, Vanderzanden L, Bray M, Custer D, Meyer B, Li D, Rossi C, Fuller D, Fuller J, Haynes J, Huggins J. Naked DNA vaccines expressing the prM and E genes of Russian spring summer encephalitis virus and Central European encephalitis virus protect mice from homologous and heterolo-gous challenge. J Virol 1997; 71:9563.

63. Aberle JH, Aberle SW, Allison SL, Stiasny K, Ecker M, Mandl CW, Berger R, Heinz FX. A DNA immunization model study with constructs expressing the tick-borne encephalitis virus envelope protein E in different physical forms. J Immunol 1999; 163:6756.

64. Bennett AM, Phillpotts RJ, Perkins SD, Jacobs SC, Williamson ED. Gene gun mediated vaccination is superior to manual delivery for immunisation with DNA vaccines expressing protective antigens from Yersinia pestis or Venezuelan Equine Encephalitis virus. Vaccine 1999; 18:588.

65. Chen HW, Pan CH, Liau MY, Jou R, Tsai CJ, Wu HJ, Lin YL, Tao MH. Screening of protective antigens of Japanese encephalitis virus by DNA immunization: A comparative study with conventional viral vaccines. J Virol 1999; 73: 10137.

66. Schmaljohn C, Custer D, VanderZanden L, Spik K, Rossi C, Bray M. Evaluation of tick-borne encephalitis DNA vaccines in monkeys. Virology 1999; 263:166.

67. Pan CH, Chen HW, Huang HW, Tao MH. Protective mechanisms induced by a Japanese encephalitis virus DNA vaccine: Requirement for antibody but not CD8( +) cytotoxic T-cell responses. J Virol 2001; 75:11457.

68. Chinsangaram J, Beard C, Mason PW, Zellner MK, Ward G, Grubman MJ. Antibody response in mice inoculated with DNA expressing foot-and-mouth disease virus capsid proteins. J Virol 1998; 72:4454.

69. Pougatcheva SO, Abernathy ES, Vzorov AN, Compans RW, Frey TK. Development of a rubella virus DNA vaccine. Vaccine 1999; 17:2104.

70. Corbeil S, Kurath G, LaPatra SE. Fish DNA vaccine against infectious hematopoietic necrosis virus: Efficacy of various routes of immunisation. Fish Shellfish Immunol 2000; 10:711.

71. Han R, Cladel NM, Reed CA, Peng X, Budgeon LR, Pickel M, Christensen ND. DNA vaccination prevents and/or delays carcinoma development of papillomavirus-induced skin papillomas on rabbits. J Virol 2000; 74:9712.

72. Han R, Reed CA, Cladel NM, Christensen ND. Immunization of rabbits with cottontail rabbit papillomavirus E1 and E2 genes: Protective immunity induced by gene gun-mediated in-tracutaneous delivery but not by intramuscular injection. Vaccine 2000; 18:2937.

73. Loehr BI, Willson P, Babiuk LA, van Drunen Littel-van den H. Gene gun-mediated DNA immunization primes development of mucosal immunity against bovine herpesvirus 1 in cattle. J Virol 2000; 74:6077.

74. Price BM, Barten Legutki J, Galloway DR, von Specht BU, Gilleland LB, Gilleland HE, Staczek J. Enhancement of the protective efficacy of an oprF DNA vaccine against Pseudomonas aeruginosa. FEMS Immunol Med Microbiol 2002; 33: 89.

Vanrompay D, Cox E, Volckaert G, Goddeeris B. Turkeys are protected from infection with Chlamydia psittaci by plasmid DNA vaccination against the major outer membrane protein. Clin Exp Immunol 1999; 118:49.

Grimm CF, Ortmann D, Mohr L, Michalak S, Krohne TU, Meckel S, Eisele S, Encke J, Blum HE, Geissler M. Mouse alpha-fetoprotein-specific DNA-based immunotherapy of hepatocellular carcinoma leads to tumor regression in mice. Gastroenterology 2000; 119:1104.

Haupt K, Siegel F, Lu M, Yang D, Hilken G, Mann K, Roggendorf M, Saller B. Induction of a cellular and humoral immune response against preprocalcitonin by genetic i: A potential new treatment for medullary thyroid carcinoma. Endocrinology 2001; 142:1017.

Hui KM, Chia TF. Eradication of tumor growth via biolistic transformation with allogeneic MHC genes. Gene Ther 1997; 4:762.

Mahvi DM, Sondel PM, Yang NS, Albertini MR, Schiller JH, Hank J, Heiner J, Gan J, Swain W, Logrono R. Phase I/IB study of immunization with autologous tumor cells transfected with the GM-CSF gene by particle-mediated transfer in patients with melanoma or sarcoma. Hum Gene Ther 1997; 8: 875.

Hawkins WG, Gold JS, Dyall R, Wolchok JD, Hoos A, Bowne WB, Srinivasan R, Houghton AN, Lewis JJ. Immunization with DNA coding for gp100 results in CD4 T-cell independent antitumor immunity. Surgery 2000; 128:273. Steitz J, Bruck J, Steinbrink K, Enk A, Knop J, Tuting T. Genetic immunization of mice with human tyrosinase-related protein 2: Implications for the immunotherapy of melanoma. Int J Cancer 2000; 86:89.

Vanderzanden L, Bray M, Fuller D, Roberts T, Custer D, Spik K, Jahrling P, Huggins J, Schmaljohn A, Schmaljohn C. DNA vaccines expressing either the GP or NP genes of Ebola virus protect mice from lethal challenge. Virology 1998; 246:134. Price BM, Liner AL, Park S, Leppla SH, Mateczun A, Galloway DR. Protection against anthrax lethal toxin challenge by genetic immunization with a plasmid encoding the lethal factor protein. Infect Immun 2001; 69:4509. Yonezawa H, Ishihara K, Okuda K. Arg-gingipain a DNA vaccine induces protective immunity against infection by Porphyromonas gingivalis in a murine model. Infect Immun 2001; 69:2858.

Sundaram P, Tigelaar RE, Brandsma JL. Intracutaneous vaccination of rabbits with the cottontail rabbit papillomavirus (CRPV) L1 gene protects against virus challenge. Vaccine 1997; 15:664.

Livingston JB, Lu S, Robinson H, Anderson DJ. Immunization of the female genital tract with a DNA-based vaccine. Infect Immun 1998; 66:322.

Vassilev VB, Gil LH, Donis RO. Microparticle-mediated RNA immunization against bovine viral diarrhea virus. Vaccine 2001; 19:2012.

Yasutomi Y, Robinson HL, Lu S, MustafaF, Lekutis C, Arthos J, Mullins JI, Voss G, Manson K, Wyand M, Letvin NL. Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys. J Virol 1996; 70:678.

Barry MA, Lai WC, Johnston SA. Protection against myco-plasma infection using expression library immunization: A general approach to vaccine development. Nature 1995; 377: 632.

Sykes KF, Lewis MG, Squires B, Johnston SA. Evaluation of SIV library vaccines with genetic cytokines in a macaque challenge. Vaccine 2002; 20:2382.

91. Haas J, Park EC, Seed B. Codon usage limitation in the expression of HIV-1 envelope glycoprotein. Curr Biol 1996; 6:315.

92. Wu L, Barry MA. Fusion protein vectors to increase protein production and evaluate the immunogenicity of genetic vaccines. Mol Ther 2000; 2:288.

93. Major ME, Vitvitski L, Mink MA, Schleef M, Whalen RG, Trepo C, Inchauspe G. DNA-based immunization with chi-meric vectors for the induction of immune responses against the hepatitis C virus nucleocapsid. J Virol 1995; 69:5798.

94. Hung CF, Hsu KF, Cheng WF, Chai CY, He L, Ling M, Wu TC. Enhancement of DNA vaccine potency by linkage of antigen gene to a gene encoding the extracellular domain of Fms-like tyrosine kinase 3-ligand. Cancer Res 2001; 61:1080.

95. Ji H, Wang TL, Chen CH, Pai SI, Hung CF, Lin KY, Kurman RJ, Pardoll DM, Wu TC. Targeting human papillomavirus type 16 E7 to the endosomal/lysosomal compartment enhances the antitumor immunity of DNA vaccines against murine human papillomavirus type 16 E7-expressing tumors. Hum Gene Ther 1999; 10:2727.

96. You Z, Huang X, Hester J, Rollins L, Rooney C, Chen SY. Induction of vigorous helper and cytotoxic T cell as well as B cell responses by dendritic cells expressing a modified antigen targeting receptor-mediated internalization pathway. J. Immunol 2000; 165:4581.

97. Sykes KF, Johnston SA. Genetic live vaccines mimic the anti-genicity but not pathogenicity of live viruses. DNA Cell Biol 1999; 18:521.

98. Fuller DH, Corb MM, Barnett S, Steimer K, Haynes JR. Enhancement of immunodeficiency virus-specific immune responses in DNA-immunized rhesus macaques. Vaccine 1997; 15:924.

99. Lu S, Santoro JC, Fuller DH, Haynes JR, Robinson HL. Use of DNAs expressing HIV-1 env and noninfectious HIV-1 particles to raise antibody responses in mice. Virology 1995; 209: 147.

100. Boyer JDea. Protection of chimpanzees from high-dose heter-ologous HIV-1 challenge by DNA vaccination. Nat Med 1997; 3:526.

101. Andre S, Seed B, Eberle J, Schraut W, Bultmann A, Haas J. Increased immune response elicited by DNA vaccination with a synthetic gp120 sequence with optimized codon usage. J. Virol 1998; 72:1497.

102. Barouch DH, Santra S, Schmitz JE, Kuroda MJ, Fu TM, Wagner W, Bilska M, Craiu A, Zheng XX, Krivulka GR, Beaudry K, Lifton MA, Nickerson CE, Trigona WL, Punt K, Freed DC, Guan L, Dubey S, Casimiro D, Simon A, Davies ME, Chastain M, Strom TB, Gelman RS, Montefiori DC, Lewis MG, Shiver JM, Letvin NL. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science 2000; 290:486.

103. Xiang ZQ, Spitalnik S, Tran M, Wunner WH, Cheng J, Ertl HC. Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus. Virology 1994; 199:132.

104. Kim JJ, Trivedi NN, Nottingham LK, Morrison L, Tsai A, Hu Y, Mahalingam S, Dang K, Ahn L, Doyle NK, Wilson DM, Chattergoon MA, Chalian AA, Boyer JD, Agadjanyan MG, Weiner DB. Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens. Eur. J. Immunol 1998; 28:1089.

105. Kim JJ, Simbiri KA, Sin JI, Dang K, Oh J, Dentchev T, Lee D, Nottingham LK, Chalian AA, McCallus D, Ciccarelli R, Agadjanyan MG, Weiner DB. Cytokine molecular adjuvants modulate immune responses induced by DNA vaccine con-

structs for HIV-1 and SIV. J Interferon Cytokine Res 1999; 19:77.

106. Sun WH, Burkholder JK, Sun J, CulpJ, Turner J, Lu XG, Pugh TD, Ershler WB, Yang NS. In vivo cytokine gene transfer by 122. gene gun reduces tumor growth in mice. Proc Natl Acad Sci USA 1995; 92:2889.

107. Xiang Z, Ertl HCJ. Manipulation of the immune response to a 123. plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity 1995; 2:129.

108. Barry MA, Johnston SA. Biological features of genetic immu- 124. nization. Vaccine 1996; 15:788.

109. Barnett SW. Vaccination with HIV-1 gp120 DNA induces immune responses that are boosted by a recombinant gp120 sub- 125. unit. Vaccine 1997; 15:869.

110. Kent SJ, Zhao A, Best SJ, Chandler JD, Boyle DB, Ramshaw IA. Enhanced T-cell immunogenicity and protective efficacy 126. of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant fowlpox virus. J Virol 1998; 72:10180. 127.

111. Condon C, Watkins SC, Celluzzi CM, Thompson K, Falo LD. DNA-based immunization by in vivo transfection of dendritic cells. Nat Med 1996; 2:1122.

112. Ulmer JB, Deck RR, Dewitt CM, Donnhly JI, Liu MA. Gener- 128. ation of MHC class I-restricted cytotoxic T lymphocytes by expression of a viral protein in muscle cells: Antigen presentation by non-muscle cells. Immunology 1996; 89:59.

113. Hanke T, McMichael AJ. Design and construction of an exper- 129. imental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat Med 2000; 6:951.

114. MacGregor RR, Boyer JD, Ugen KE, Lacy KE, Gluckman SJ, Bagarazzi ML, Chattergoon MA, Baine Y, Higgins TJ, 130. Ciccarelli RB, Coney LR, Ginsberg RS, Weiner DB. First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: Safety and host response. J Infect Dis 1998; 178:92.

115. BoyerJD, Cohen AD, Vogt S, Schumann K, Nath B, Ahn L, 131. Lacy K, Bagarazzi ML, Higgins TJ, Baine Y, Ciccarelli RB, Ginsberg RS, MacGregor RR, Weiner DB. Vaccination of seronegative volunteers with a human immunodeficiency virus type 1 env/rev DNA vaccine induces antigen-specific proliferation and lymphocyte production of beta-chemokines. J Infect 132. Dis 2000; 181:476.

116. Ugen KE, Nyland SB, Boyer JD, Vidal C, Lera L, Rasheid S, Chattergoon M, Bagarazzi ML, Ciccarelli R, Higgins T, Baine Y, Ginsberg R, Macgregor RR, Weiner DB. DNA vaccination with HIV-1 expressing constructs elicits immune re- 133. sponses in humans. Vaccine 1998; 16:1818.

117. Boyer JD, Chattergoon MA, Ugen KE, Shah A, Bennett M, Cohen A, Nyland S, Lacy KE, Bagarazzi ML, Higgins TJ, Baine Y, Ciccarelli RB, Ginsberg RS, MacGregor RR, Weiner DB. Enhancement of cellular immune response in HIV-1 sero- 134. positive individuals: A DNA-based trial. Clin Immunol 1999; 90:100.

118. Mincheff M, Tchakarov S, Zoubak S, Loukinov D, Botev C, Altankova I, Georgiev G, Petrov S, Meryman HT. Naked DNA 135. and adenoviral immunizations for immunotherapy of prostate cancer: A phase I/II clinical trial. Eur Urol 2000; 38:208.

119. Timmerman JM, Singh G, Hermanson G, Hobart P, Czerwin-ski DK, Taidi B, Rajapaksa R, Caspar CB, Van Beckhoven A, Levy R. Immunogenicity of a plasmid DNA vaccine encoding 136. chimeric idiotype in patients with B-cell lymphoma. Cancer Res 2002; 62:5845.

120. Sun W, Li N, He S. Large-scale morphological survey of mouse retinal ganglion cells. J Comp Neurol 2002; 451:115.

121. Raz E, Carson DA, Parker SE, Parr TB, Abai AM, Aichinger 137. G, Gromkowski SH, Singh M, Lew D, Yankauckas MA, Baird

SM, Rhodes GH. Intradermal gene immunization: The possible role of DNA uptake in the induction of cellular immunity to viruses. Proc Natl Acad Sci USA 1994; 91:9519. Liu F, Song Y, Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 1999; 6:1258.

Zhang G, Budker V, Wolff JA. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther 1999; 10:1735. Ulmer JB, Donnelly JJ, Liu MA. Presentation of an exogenous antigen by major histocompatibility complex class I molecules. Eur J Immunol 1994; 24:1590. Cho JH, Youn JW, Sung YC. Cross-priming as a predominant mechanism for inducing CD8( + ) T cell responses in gene gun DNA immunization. J Immunol 2001; 167:5549. Timares L, Takashima A, Johnston SA. Quantitative analysis of the immunopotency of genetically transfected dendritic cells. Proc Natl Acad Sci USA 1998; 95:13147. Klinman DM, Yi AK, Beaucage SL, Conover J, Krieg AM. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. PNAS 1996; 93:2879.

Roman M, Martin-Orozco E, Goodman JS, Nguyen MD, Sato Y, Ronaghy A, Kornbluth RS, Richman DD, Carson DA, Raz E. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat Med 1997; 3:849. Pertmer TM, Roberts TR, Haynes JR. Influenza virus nucleo-protein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery. J. Virol 1996; 70:6119. Degano P, Schneider J, Hannan CM, Gilbert SC, Hill AV. Gene gun intradermal DNA immunization followed by boosting with modified vaccinia virus Ankara: Enhanced CD8 + T cell immunogenicity and protective efficacy in the influenza and malaria models. Vaccine 1999; 18:623. Pertmer TM, Eisenbraun MD, McCabe D, Prayaga SK, Fuller DH, Haynes JR. Gene gun-based nucleic acid immunization: Elicitation of humoral and cytotoxic T lymphocyte responses following epidermal delivery of nanogram quantities of DNA. Vaccine 1995; 13:1427.

Lodmell DL, Parnell MJ, Bailey JR, Ewalt LC, Hanlon CA. One-time gene gun or intramuscular rabies DNA vaccination of non-human primates: Comparison of neutralizing antibody responses and protection against rabies virus 1 year after vaccination. Vaccine 2001; 20:838.

Tuting T, Gambotto A, Robbins PD, Storkus WJ, DeLeo AB. Co-delivery of T helper 1-biasing cytokine genes enhances the efficacy of gene gun immunization of mice: Studies with the model tumor antigen beta-galactosidase and the BALB/c Meth A p53 tumor-specific antigen. Gene Ther 1999; 6:629. Roy K, Mao HQ, Huang SK, Leong KW. Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat Med 1999; 5:387.

Hartl A, Kiesslich J, Weiss R, Bernhaupt A, Mostbock S, Scheiblhofer S, Flockner H, Sippl M, Ebner C, Ferreira F, Thalhamer J. Isoforms of the major allergen of birch pollen induce different immune responses after genetic immunization. Int Arch Allergy Immunol 1999; 120:17. Adel-Patient K, Creminon C, Boquet D, Wal JM, Chatel JM. Genetic immunisation with bovine beta-lactoglobulin cDNA induces a preventive and persistent inhibition of specific anti-BLG IgE response in mice. Int Arch Allergy Immunol 2001; 126:59.

Balasa B, Boehm BO, Fortnagel A, Karges W, Van Gunst K, Jung N, Camacho SA, Webb SR, Sarvetnick N. Vaccination with glutamic acid decarboxylase plasmid DNA protects mice from spontaneous autoimmune diabetes and B7/CD28 costi-mulation circumvents that protection. Clin Immunol 2001; 99: 241.

Waisman A, Ruiz PJ, Hirschberg DL, Gelman A, Oksenberg JR, Brocke S, Mor F, Cohen IR, Steinman L. Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Nat Med 1996; 2:899. Han R, Cladel NM, Reed CA, Peng X, Christensen ND. Protection of rabbits from viral challenge by gene gun-based intra-cutaneous vaccination with a combination of cottontail rabbit papillomavirus E1, E2, E6, and E7 genes. J Virol 1999; 73: 7039.

Tuting T, Gambotto A, DeLeo A, Lotze MT, Robbins PD, Storkus WJ. Induction of tumor antigen-specific immunity using plasmid DNA immunization in mice. Cancer Gene Ther 1999; 6:73.

Hui KM, Sabapathy TK, Oei AA, Chia TF. Generation of alloreactive cytotoxic T lymphocytes by particle bombardment-mediated gene transfer. J Immunol Methods 1994; 171: 147.

Gainer AL, Young ATL, Parney IF, Petruk KC, Elliott JF. Gene gun transfection of human glioma and melanoma cell lines with genes encoding human IL-12 and GM-CSF. J Neu-rooncol 2000; 47:23.

Seigne J, Turner J, Diaz J, Hackney J, Pow-Sang J, Helal M, Lockhart J, Yu H. A feasibility study of gene gun mediated immunotherapy for renal cell carcinoma. J Urol 1999; 162: 1259.

Mahvi DM, Burkholder JK, Turner J, Culp J, Malter JS, Sondel PM, Yang NS. Particle-mediated gene transfer of granulocyte-macrophage colony-stimulating factor cDNA to tumor cells: Implications for a clinically relevant tumor vaccine. Hum Gene Ther 1996; 7:1535.

Dietrich A, Kraus K, Brinckmann U, Friedrich T, Muller A, Liebert UG, Schonfelder M. Complex cancer gene therapy in mice melanoma. Langenbecks Arch Surg 2002; 387:177. Wang J, Murakami T, Hakamata Y, Ajiki T, Jinbu Y, Akasaka Y, Ohtsuki M, Nakagawa H, Kobayashi E. Gene gun-mediated oral mucosal transfer of interleukin 12 cDNA coupled with an irradiated melanoma vaccine in a hamster model: Successful treatment of oral melanoma and distant skin lesion. Cancer Gene Ther 2001; 8:705.

Rakhmilevich AL, Janssen K, Hao Z, Sondel PM, Yang NS. Interleukin-12 gene therapy of a weakly immunogenic mouse mammary carcinoma results in reduction of spontaneous lung metastases via a T-cell-independent mechanism. Cancer Gene Ther 2000; 7:826.

Tanigawa K, Yu H, Sun R, Nickoloff BJ, Chang AE. Gene gun application in the generation of effector T cells for adoptive immunotherapy. Cancer Immunol Immunother 2000; 48:635. Oshikawa K, Ishii Y, Hamamoto T, Sugiyama Y, Kitamura S, Kagawa Y. Particle-mediated gene transfer of murine in-terleukin-12 cDNA suppresses the growth of Lewis lung carcinoma. In Vivo 1999; 13:397.

Oshikawa K, Shi F, Rakhmilevich AL, Sondel PM, Mahvi DM, Yang NS. Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1beta converting enzyme cDNA. Proc Natl Acad Sci USA 1999; 96:13351. Rakhmilevich AL, Timmins JG, Janssen K, Pohlmann EL, Sheehy MJ, Yang NS. Gene gun-mediated IL-12 gene therapy induces antitumor effects in the absence of toxicity: A direct comparison with systemic IL-12 protein therapy. J Immu-nother 1999; 22:135.

152. Moller P, Sun Y, Dorbic T, Alijagic S, Makki A, Jurgovsky K, Schroff M, Henz BM, Wittig B, Schadendorf D. Vaccination with IL-7 gene-modified autologous melanoma cells can enhance the anti-melanoma lytic activity in peripheral blood of patients with a good clinical performance status: a clinical phase I study. Br J Cancer 1998; 77:1907.

153. Sun Y, Jurgovsky K, Moller P, Alijagic S, Dorbic T, Georgieva J, Wittig B, Schadendorf D. Vaccination with IL-12 gene-modified autologous melanoma cells: Preclinical results and a first clinical phase I study. Gene Ther 1998; 5:481.

154. Davidson JM, Krieg T, Eming SA. Particle-mediated gene therapy of wounds. Wound Repair Regen 2000; 8:452.

155. Byrnes CK, Khan FH, Nass PH, Hatoum C, Duncan MD, Harmon JW. Success and limitations of a naked plasmid transfec-tion protocol for keratinocyte growth factor-1 to enhance cutaneous wound healing. Wound Repair Regen 2001; 9:341.

156. Kuwahara H, Mitchell AT, Macklin MD, Zhao J, Listengarten D, Phillips LG. Transfer of platelet-derived growth factor-BB gene by gene gun increases contraction of collagen lattice by fibroblasts in diabetic and non-diabetic human skin. Scand J Plast Reconstr Surg Hand Surg 2000; 34:301.

157. Nanney LB, Paulsen S, Davidson MK, Cardwell NL, Whitsitt JS, Davidson JM. Boosting epidermal growth factor receptor expression by gene gun transfection stimulates epidermal growth in vivo. Wound Repair Regen 2000; 8:117.

158. Lu CY, Chou AK, Wu CL, Yang CH, Chen JT, Wu PC, Lin SH, Muhammad R, Yang LC. Gene-gun particle with pro-opiomelanocortin cDNA produces analgesia against formalin-induced pain in rats. Gene Ther 2002; 9:1008.

159. Suber ML, Hurwitz MY, Chevez-Barrios P, Hurwitz RL. Immune consequences of intraocular administration of modified adenoviral vectors. Hum Gene Ther 2001; 12:833.

160. Shestopalov VI, Missey H, Bassnett S. Delivery of genes and fluorescent dyes into cells of the intact lens by particle bombardment. Exp Eye Res 2002; 74:639.

161. Rockhill RL, Daly FJ, MacNeil MA, Brown SP, Masland RH. The diversity of ganglion cells in a mammalian retina. J Neu-rosci 2002; 22:3831.

162. Wang IJ, Carlson EC, Liu CY, Kao CW, Hu FR, Kao WW. Cis-regulatory elements of the mouse Krt1.12 gene. Mol Vis 2002; 8:94.

163. Konig Merediz SA, Zhang EP, Wittig B, Hoffmann F. Ballistic transfer of minimalistic immunologically defined expression constructs for IL4 and CTLA4 into the corneal epithelium in mice after orthotopic corneal allograft transplantation. Graefes Arch Clin Exp Ophthalmol 2000; 238:701.

164. Klimaschewski L, Nindl W, Pimpl M, Waltinger P, Pfaller K. Biolistic transfection and morphological analysis of cultured sympathetic neurons. J Neurosci Methods 2002; 113:63.

165. Gan WB, Grutzendler J, Wong WT, Wong RO, Lichtman JW. Multicolor ''DiOlistic'' labeling of the nervous system using lipophilic dye combinations. Neuron 2000; 27:219.

166. Ghoumari AM, Wehrle R, De Zeeuw CI, Sotelo C, Dusart I. Inhibition of protein kinase C prevents Purkinje cell death but does not affect axonal regeneration. J Neurosci 2002; 22:3531.

167. Zhang G, Selzer ME. In vivo transfection of lamprey brain neurons by gene gun delivery of DNA. Exp Neurol 2001; 167: 304.

168. Sato H, Hattori S, Kawamoto S, Kudoh I, Hayashi A, Yama-moto I, Yoshinari M, Minami M, Kanno H. In vivo gene gun-mediated DNA delivery into rodent brain tissue. Biochem Bio-phys Res Commun 2000; 270:163.

169. Harimoto K, Sugimura K, Lee CR, Kuratsukuri K, Kishimoto T. In vivo gene transfer methods in the bladder without viral vectors. Br J Urol 1998; 81:870.

170. Nishizaki K, Mazda O, Dohi Y, KawataT, Mizuguchi K, Kitamura S, Taniguchi S. In vivo gene gun-mediated transduction into rat heart with Epstein-Barr virus-based episomal vectors. 174.

Ann Thorac Surg 2000; 70:1332.

171. Nishizaki K, Mazda O, Dohi Y, Satoh E, Kawata T, Mizuguchi K, Yonemasu K, Kitamura S, Taniguchi S. In vivo gene transfer into rat hearts with Epstein-Barr virus-based episomal vectors using a gene gun. Transplant Proc 2000; 32:2413. 175.

172. Muangmoonchai R, Wong SC, Smirlis D, Phillips IR, Sheph-ardl EA. Transfection of liver in vivo by biolistic particle delivery: Its use in the investigation of cytochrome P450 gene regulation. Mol Biotechnol 2002; 20:145.

173. Eizema K, van Heugten HA, Bezstarosti K, van Setten MC,

Lamers JM. Endothelin-1 responsiveness of a 1.4 kb phospho- 176. lamban promoter fragment in rat cardiomyocytes transfected by the gene gun. J Mol Cell Cardiol 2000; 32:311.

Yoshida Y, Kobayashi E, Endo H, Hamamoto T, Yamanaka T, Fujimura A, Kagawa Y. Introduction of DNA into rat liver with a hand-held gene gun: Distribution of the expressed enzyme, [32P]DNA, and Ca2 + flux. Biochem Biophys Res Commun 1997; 234:695.

Yanai K, Hirota K, Taniguchi-Yanai K, Shigematsu Y, Shima-moto Y, Saito T, Chowdhury S, Takiguchi M, Arakawa M, Nibu Y, Sugiyama F, Yagami K, Fukamizu A. Regulated expression of human angiotensinogen gene by hepatocyte nuclear factor 4 and chicken ovalbumin upstream promoter-transcription factor. J Biol Chem 1999; 274:34605. Singh RA, Wu L, Barry MA. The role of T cell antagonism and original antigenic sin in genetic immunization. J Immunol 2002; 169.

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