Mri

Tyrosinase

Hydroxylation

Melanin production

(110)

Living Optical: Fluorescence

Green fluorescent protein

Light excitation

None (irradiation)

(18)

subjects

Red fluorescent protein (dsRed)

Light excitation

None (irradiation)

(111)

Optical: Fluorescence

Cathepsin D

Enzymatic cleavage

Quenched NIRF fluorochromes

(19)

activation

Matrix metalloproteinase (MMP2)

Enzymatic cleavage

Quenched NIRF fluorochromes

(44)

Optical:

Luciferase (Firefly)

Luciferase-D-Luciferin

D-Luciferin

(35)

Bioluminescence

0 0

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