Conclusions And Future Prospects

To date, retroviral vectors have been the most commonly used gene delivery vehicle in human gene therapy protocols. The simplicity of their design, their broad host range and their ability to integrate into a cell's genome are responsible for their popularity. As with any viral vector system, the potential for RCR formation remains a concern, even with the latest vector designs, but assays are in place to detect such recombinants and guidelines for the production of clinical grade vectors are well established. The risk of insertional mutagenesis is recognized as a downside of their ability to integrate, and highlights the fact that this therapy should be used only in cases where the benefits outweigh the risks.

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