Liposome Morphology And Effects On Gene Delivery And Expression

Efficient in vivo nucleic acid-liposome complexes have unique features, including their morphology, mechanisms for crossing the cell membrane and entry into the nucleus, ability to be targeted for delivery to specific cell surface receptors, and ability to penetrate across tight barriers and throughout target tissues. Liposomes have different morphologies based on their composition and the formulation method. Furthermore, the morphology of complexes can contribute to their ability to deliver nucleic acids in vivo. Formulations frequently used for the delivery of nucleic acids are lamellar structures, including small unilamellar vesicles (SUVs), multilamellar vesicles (MLVs), or bilamel-lar invaginated vesicles (BIVs), recently developed in our laboratory (Fig. 1). Several investigators developed liposomal delivery systems using hexagonal structures; however,

Types of Lamellar Vesicles

SUV ii

0 0

Post a comment