Flexibility of Gene Expression Strategies

Because the 5' retroviral LTR is itself a promoter, the simplest vector design uses the LTR to drive transgene expression (36) (Fig. 5). In addition, the use of heterologous promoters placed internally within the retroviral transcription unit increase the flexibility of gene expression, as constitutive, inducible, or tissue-specific promoters can be included. Expression of more

Single gene, LTR promoter

Two genes

ILTR^H

(■Ja.)

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