Cd

Aerosol to airway

RG Crystal, BG Harvey

aCompiled from the 143 protocols in the RAC database as of February 2003. Duplicate, closely related protocols from the same investigator are listed only once. Protocols are organized first by general area, therapeutic approach, transgene and then route of administration.

Abbreviations: CFTR, cystic fibrosis transmembrane regulator; OTC, ornithine transcarbamylase; AFP, alpha fetoprotein; CD40D, CD40 ligand; IL, interleukin; GM-CSF, granulocyte macrophage colony-stimulating factor; IFN, interferon; PSA, prostate-specific antigen; TNF, tumor necrosis factor; HSV-TK, herpes simplex virus thymidine kinase; CD, cytosine deaminase; VEGF, vascular endothelial growth factor; FGF, fibroblast growth factor; HIF, hypoxia-inducible factor; PDGF, platelet-derived growth factor; PEDF, pigment epithelium-derived factor; NSCLC, non-small-cell lung cancer.

aCompiled from the 143 protocols in the RAC database as of February 2003. Duplicate, closely related protocols from the same investigator are listed only once. Protocols are organized first by general area, therapeutic approach, transgene and then route of administration.

Abbreviations: CFTR, cystic fibrosis transmembrane regulator; OTC, ornithine transcarbamylase; AFP, alpha fetoprotein; CD40D, CD40 ligand; IL, interleukin; GM-CSF, granulocyte macrophage colony-stimulating factor; IFN, interferon; PSA, prostate-specific antigen; TNF, tumor necrosis factor; HSV-TK, herpes simplex virus thymidine kinase; CD, cytosine deaminase; VEGF, vascular endothelial growth factor; FGF, fibroblast growth factor; HIF, hypoxia-inducible factor; PDGF, platelet-derived growth factor; PEDF, pigment epithelium-derived factor; NSCLC, non-small-cell lung cancer.

expression of the therapeutic gene. Demonstrations of actual therapeutic benefit will require critical placebo-controlled testing. If an Ad vector does prove to be effective in a large study, there remain substantial production and support issues that will require a significant investment of time and money to provide the reliable supply of a marketed drug.

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