Brief History Of Biolistics And Gene Guns

Genes Figure Cartoon

Biolistic technology was originally developed in the area of plant genetics to introduce genes into target cells that were largely refractory to traditional methods of gene delivery (1). Biolistic lore holds that the gene gun was inspired by interactions between edible bonsai plants and squirrels, and the later involvement of an air rifle to control these interactions. Legend has it that in the course of those events, Dr. John Sanford made the pivotal extrapolation that if an air rifle could be...