Prostate Cancer

Malcolm D Mason

Abstract: Prostate cancer is a major cause of death from cancer among men in the Western world. It's most striking clinical peculiarity is its tendency to metastasise to bone, resulting in osteoblastic (sclerotic) deposits. This phenomenon may be related to anatomical factors, or to specific biological factors. These include alterations in the expression of adhesion molecules by prostate cancer cells (such as reduced E-Cadherin expression or function, loss of integrins such as a4, a5, and av). The production of growth factors and cytokines such as TGFP or IGF may mediate crosstalk between bone cells and prostate cancer cells. An understanding of these various factors may result in novel approaches to the treatment of metastatic prostate cancer. Other factors which impact on earlier stages of metastasis, such as expression of the collagenase uPA, might also be amenable to therapeutic intervention, but the applicability of such interventions in patients with already established metastatic disease remains to be demonstrated.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

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