Metastasis And Invasion

The expression of a certain number of genes in a variety of different experimental systems has been shown to result in a positive modulation or gain in function that can affect the metastatic capacity in vitro and in vivo (23). It is likely, though, that the majority of these effects are indirect and thus attention has been focussed on changes specific to tumour cells themselves. Such changes include altered expression of cell surface adhesion molecules (cadherins, integrins and immunoglobulin superfamily members) and the expression of tissue-degrading enzymes (matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs)).

0 0

Post a comment