Triplenegative breast cancer treatment

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CCN1, also known as Cyr61 (cysteine-rich 61), is a proangiogenic factor, increased CCN1 expression is associated with the development of tumors (O'Kelly et al., 2008), e.g., in about 30% of invasive breast carcinomas, and particularly in triple-negative breast carcinomas (TNBC). TNBCs patients had been treated with bisphosphonate in combination to chemotherapy. Zoledronic acid (ZOL) is a bisphosphonate having direct antitumor activity in breast tumor cells by preventing independent growth, branching and morphogenesis by targeting CCN1 overexpressing cells through a negative regulation of CCN1 by FOXO3a; it is a new therapeutic approach for TNBC (Espinoza et al., 2011).

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10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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