HR breast cancer and targeted therapy

Estrogen is a well-characterized growth factor in about 60-70% of breast cancer patients (Clemons and Goss, 2001). The malignant epithelial cells depend on reproductive hormones, specifically estrogen in ER+ tumors (Heldermon and Ellis, 2006). The initial endocrine therapy of breast cancer was removal of the ovaries (oophorectomy) (Taylor et al., 1998). Many thriving remedies have been formulated to decrease or eradicate circulating estrogen or to obstruct its communication with genomic target objects. The specific ER antagonist tamoxifen is recommended as adjuvant endocrine therapy for the hormone receptor positive early breast cancer (Sehdev et al., 2009). Endocrine therapies for ER+ patients include three types of agents that (i) directly target ER through molecules that bind ER and change ER function; (ii) estrogen deprivation through aromatase inhibition or ovarian suppression; and (iii) sex steroid therapies, including estrogen, progestins and androgens.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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