CXCR4 is receptor for chemokine CXCL12. In NSCLC, tumor cells at stage 1 show expression of CXCR4, present in the nucleus and cytoplasm of these tumor cells. Several studies on tumor cells show that CXCR4 positive nuclear staining is related with improve survival rate. The 5 year overall survival rate was 93% for the patients having strong nuclear staining 52% for those having weak nuclear staining 10.
CXCL12 and its receptor CXCR4 promote metastasis of different tumors having angiogenic phenotype including NSCLC 17;32;40-42.CXCR4 may transform a benign tumor to malignant phenotype 17;43.
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