Biological explanation of breast cancer

Breast cancer usually arises after menopause (age: 40+), but it can also arise before menopause in very rare cases. The ovarian-pituitary axis synchronizes the normal breast physiology during the reproductive cycle. The biological reason for it is that the glandular component of the breast gradually degenerates after menopause and the breast is mostly substituted by adipose tissue. Any problem in this process causes the development of breast cancer, whereas by epithelial cells of the breast ducts, uncontrolled growth and survival takes place, and in later stages the characteristics of neo-angiogenesis, invasion and metastasis occurs (Heldermon and Ellis, 2006).

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