Mouse Double Minute4

MDM-4 (MDMX) was identified as a binding partner of p53 and shows structural homology to MDM-2, and is thus a potentially important regulator of p53. When bound to p53 it inhibits p53 transactivation, but does not appear to target p53 for degradation as it lacks the E3 ubiquitin ligase function of MDM-2. MDMX overexpression can protect p53 from MDM-2-mediated degradation while still maintaining suppression of p53 transactivation.35 The gene for MDMX is overexpressed or amplified in 10-20% of diverse tumor types including breast cancer.27 Like MDM-2, MDMX knockout mice are embryonic lethal, although this can be rescued by being in a p53-deficient background. It has been suggested that to fully activate p53 both MDM-2 and MDMX need to be inactivated, which adds another level of complexity when trying to discover ways of exploiting p53 for therapeutic gain.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

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