Detection Of Disseminated Tumor Cells And Circulating Tumor Cells

Both early diagnosis of breast cancer and identification of metastases can improve the success of breast cancer treatment.4 Two approaches currently under close scrutiny for diagnostic and prognostic use are detection of disseminated tumor cells (DTCs) and detection of circulating tumor cells (CTCs), as discussed in Chapter 7. Although the risk of invasive bone marrow aspiration has made its routine use for breast cancer screening and follow-up problematic for patients, a number of groups have successfully detected DTCs in the bone marrow in primary breast cancer patients (reviewed by Slade and Coombes5). Detection of CTCs in the blood is obviously a much less invasive procedure. Their presence probably reflects a relapse or metastasis; hence, detection of CTCs may be most useful in metastatic disease and for monitoring of the adjuvant situation.6 However, CTCs have been detected at a low frequency in early stage disease7 and recently CTCs were detected in 10 of 35 (29%) stage I patients using a sensitive quantitative (q) reverse transcription polymerase chain reaction (RT-PCR) assay.8 These data highlight the need for larger scale studies comparing detection of DTCs and CTCs in early stage disease, and comparing sensitivity and specificity with assessment of cell-free nucleic acids in the circulation.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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