Is there a danger in taking benzodiazepines during pregnancy

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Benzodiazepines target the GABAa (y-aminobutyric acid A) chloride channel receptor, resulting in an increase in the receptor's affinity for and causing the ion channels to open more frequently, thus allowing more chloride ions to pass through.

Benzodiazepines can cross the placenta, and therefore should not be taken during pregnancy if possible. They are categories D and X.

There are three phases.

1. Phase 1: The R1 and R2 residues are oxidized.

2. Phase 2: The R3 residue is hydroxylated.

3. Phase 3: The hydroxyl compounds are conjugated with glucuronic acid.

Where does benzodiazepine In the liver metabolism occur?

Which benzodiazepines skip phase 1 and/or phase 2 of metabolism and are therefore safer to give to patients with liver failure?

Triazolam

What are the symptoms of Anxiety benzodiazepine withdrawal? Insomnia

Irritability Delirium, Psychosis Weakness Tremor Seizures

Drowsiness Confusion

Motor incoordination Cognitive impairment Anterograde amnesia

How many phases are there in benzodiazepine metabolism?

Desmethyldiazepam

Oxazepam

Temazepam

Lorazepam

Midazolam

What are the possible side effects of benzodiazepines?

Which benzodiazepines are considered Triazolam to be high potency? Alprazolam

Clonazepam

Which benzodiazepines are considered to be low potency?

Which benzodiazepines are most commonly used for treatment of alcohol withdrawal seizures (delirium tremens)?

Diazepam

Chlordiazepoxide

Oxazepam

Chlordiazepoxide

Lorazepam

Diazepam

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