Mssa

Aminoglycosides

Gentamicin P aeruginosa, GNB

240 mg (IV) q24h Tobramycin P aeruginosa, GNB

240 mg (IV) q24h Amikacin P aeruginosa, GNB

1 g (IV) q24h 1st generation cephalosporin Cefazolin MSSA, Klebsiella

Oral antibiotic (usual dose)

Oral Peak serum bioavailability concentration

Amoxicillin 90% 16 ng/mL

Cephalexin 99% 36 ng/mL

Moxifloxacin 90% 4.5 ng/mL

Levofloxacin 99% 8 |xg/mL

Gatifloxacin 96% 4.2 ng/mL

Telithromycin 57% 2.2 |xg/mL

Levofloxacin 70% 2.9 |xg/mL

Ciprofloxacin 90% 8 |xg/mL

Cephalexin 99% 36 ng/mL

2nd generation cephalosporin Cefuroxime 1.5 g (IV) q8h 3rd generation cephalosporins Ceftriaxone 1-2 g (IV) ql2-24h Cefotaxime 2 g (IV) q6h

Ceftizoxime

2 g (IV) q8h Cefoperazone 2 g (IV) ql2h 4th generation cephalosporin Cefepime

Monobactam Aztreonam 2 g (IV) q8h

Carbapenems Meropenem 500 mg (IV) q8h

MSSA, Klebsiella, H influenzae

MSSA, GNB

MSSA, GNB, Bfragilis

P aeruginosa, GNB

P aeruginosa, GNB

P aeruginosa, GNB

MSSA, VSE, Bfragilis

Cefprozil 95%

10 ng/mL

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