0025-7125/06/$ - see front matter © 2006 Elsevier Inc. All rights reserved. doi:10.1016/j.mcna.2006.07.001 medical.theclinics.com combination therapy for various infectious diseases, which are ably reviewed by Dr. Louis Saravoltaz. Older antibiotics are being "rediscovered" for new uses against resistant organisms. An article by the author focusing on new uses for older antibiotics is also included in this issue.

Antibiotic resistance among gram-positive cocci is a problem worldwide. Multidrug-resistant Streptococcus pneumonia, vancomycin-resistant entero-cocci, and methicillin-resistant Staphylcoccus aureus are the most frequently encountered gram-positive therapeutic challenges for physicians. Nationally, there is an underrecognized and underappreciated epidemic of macro-lide-resistant S pneumoniae, and this important topic is well reviewed by Dr. Gary Doern.

The antimicrobial therapies for Helicobacter pylori and Clostridium difficile diarrhea/colitis remain thorny therapeutic problems. Key components of this issue are articles reviewing the current state of the art for the antimicrobial therapy of H pylori, by Dr. Duane Smoot, and for that of C difficile diarrhea/colitis, by Dr. Emilio Bouza.

The remaining articles are devoted to potential problems related to antimicrobial prescription. The common dilemma of selecting an antibiotic in the penicillin-allergic patient is reviewed by the author. The important topic of antibiotic drug interactions is carefully covered by Dr. Keith Rodvold. The issue concludes with the important subject of apparent antibiotic failure, covered by Dr. David Schlossberg.

This issue of the Medical Clinics of North America on Antimicrobial Therapy is an up-to-date desk reference source dealing with the most important clinical problems related to antimicrobial therapy that are currently faced by physicians.

Burke A. Cunha, MD, MACP Chief, Infectious Disease Division Winthrop-University Hospital Minneola, NY 11501

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