Rheumatoid Factor Negative Polyarthritis JIA

This subtype is classified as a polyarthritis affecting five or more joints during the first six months of disease in the absence of a consistently raised rheumatoid factor. Onset is most frequently in girls below the age of seven. There is a much lower risk and severity of erosive changes on X ray and extra-articular manifestations than in rheumatoid factor positive JIA and prognosis is less severe. There is an association to chronic asymptomatic anterior uveitis, but with a lower incidence than in the oligo-arthritis JIA subset, but there is a similar association with ANA positivity.

In adults with rheumatoid arthritis, there is a subgroup of 25% of patients who are rheumatoid factor negative. In this adult seronegative subgroup, erosive joint damage and extra-articular manifestations are less common than in rheumatoid factor positive disease. The occult anterior uveitis and ANA positivity associations seen in juveniles are not, however, seen in adult disease.

Treating Rheumatoid Arthritis With Herbs Spices Roots

Treating Rheumatoid Arthritis With Herbs Spices Roots

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