The proportion of patients with active disease in long-standing JIA ranges between 31% and 55% (2,3,6,26-32), depending upon the selection and severity of the population studied.
There does not appear to be a reduction in disease activity as disease duration increases. Continuing high levels of inflammation (CRP/ESR) are related to poor physical function (HAQ) (Table 5) (3).
Systemic onset JIA is associated with the highest levels of inflammation in the pediatric population and the worst long-term functional outcome. However, in adulthood the levels of clinical inflammation are significantly lower than any other subset (2,3). This suggests that the concept of arthritis "burning out" may hold true in this specific subtype.
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