In many of the diffuse pain conditions, there is a history of a preceding illness including glandular fever, tonsillitis, and influenza. Diffuse and localized chronic pains can also complicate almost any other chronic childhood illness (16) including juvenile arthritis, inflammatory bowel disease (17), cerebral palsy, cancer (18), sickle cell disease (19), muscular dystrophies (20) and cystic fibrosis (21).

It is difficult to know whether the direct infectious or inflammatory condition has effect on the evolution of chronic pain or whether the pain is a consequence of the immobility, medical therapies, environmental changes, etc. There is a strong association between joint hypermobility and diffuse pain (22).

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