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The rationale for use of carbimide in alcoholism treatment is similar to that of disulfiram. The threat of an unpleasant reaction, which one may expect following drinking, is sufficient to deter drinking. For alcoholics in treatment who take a drink, the ensuing reaction is unpleasant enough to strengthen their overall conditioned aversion to alcohol. Their reduction of alcohol consumption during carbimide treatment is expected to result in general bodily improvement. A second approach involves the use of carbimide as part of a RELAPSE-PREVENTION treatment, whereby an individual might take it in anticipation of a high-risk situation. As of 2000, scientific evidence supporting the efficacy of carbimide in alcoholism treatment is inconclusive because of a lack of well-controlled clinical trials. No multicenter clinical trials have yet been performed.

(SEE ALSO: Causes of Substance Abuse: Learning; Disulfiram; Treatment Types: Aversion Therapy)


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Peachey, J. E., & Annis, H. (1985). New strategies for using the alcohol-sensitizing drugs. In C. A. Naranjo & E. M. Sellers (Eds.). Research advances in newpsy-chopharmacological treatments for alcholism (pp. 199-218). New York: Excerpta Medica. Peachey, J. E. ET AL. (1989a). Calcium carbimide in alcoholism treatment. Part 1: A placebo-controlled, double-blind clinical trial of short-term efficacy. British Journal of Addiction, 84, 877-887. PEACHEY, J. E. ET AL. (1989b). Calcium carbimide in alcoholism treatment. Part 2: Medical findings of a short-term, placebo-controlled, double-blind clinical trial. British Journal of Addiction, 84, 1359-1366.

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