Unique Features

The plasma membrane of neurons differs from that of non-neuronal cells in that it contains special proteins, termed voltage-sensitive ion channels. Such channels are conceptually small tubular proteins embedded in the membrane of the neuron, which, when activated under specific conditions, allow positively charged ions of sodium, potassium, and calcium to enter the neuron. The existence of such electrically sensitive channels permits the neuron to become electrically excitable. The expression and selective distribution (compartmentalization) of such electrically excitable channels along its efferent processes, the axons, permit neurons to conduct signals efficiently for long distances; this also accounts for the bioelectrical activity of the brain assessed by electroencephalography (EEG). Simi larly, the distribution of such electrically excitable ion channels along the receptive surfaces of the neurons (its dendrites and cell body [soma]) allows them to conduct and integrate signals from all over the extended shape of the neuron.

The smooth endoplasmic reticulum of the neuron is somewhat more elaborate and extensive than other cells that secrete their products; this specialized and extensive smooth endoplasmic system is termed the Golgi complex (or Golgi apparatus). Discovered accidentally, it was a useful marker for staining the nervous system to distinguish neurons from other cells of the brain when under inspection by microscope.

The nucleus of neurons is often highly elaborated, with multiple creases or infoldings, exhibiting complex configurations, within which are typically dense accumulations of cytoplasmic organelles, and almost always a very distinctive intranuclear clustering of genetic material, the nucleolus. Differentiated neurons—neurons whose developmental stage is past the step at which cell-

Figure 4

Relationship of Receptor Types. Efferent nerves in the peripheral nervous system. (Receptor subdivisions for alpha and dopaminergic receptors are not included.)

type dedication has occurred—are unable to undergo cell division, in distinct contrast to comparably metabolically active cells in such complex tissues as liver, kidney, muscle, or skin. As a result, mature neuronsBcan repair themselves, up to a point, but! are unable to regenerate themselves or respond to their growth factors in a manner that would in other tissues lead to cell division and replacement.

The most distinctive cellular feature of neurons is the degree to which they express unique patterns of size and shape. In mammals, all neurons have highly irregular shapes; such shape variations are categorized in terms of the number of cell surface extensions, or neuronal processes, that the neuronal subset expresses, as in Figure 2.

Some neurons have only one cellular process extending from the surface of a round or nearly round cell body; this form of neuron, a unipolar neuron, is typical of invertebrate nervous systems. Typical unipolar neurons are the cells of the dorsal root ganglia, in which a single efferent axon conducts information toward or away from the cell body through a branched axon.

Most neurons of the central nervous system of mammals are multipolar. That is, in addition to the efferent axon, which may also have many subsets of secondary axons, called collateral branches, that stem from the main efferent process axon, elaborations may also be expressed from the cell body surface. The latter elaborations are termed dendrites, because their shape resembles the limbs of trees. Dendrites protrude from the cell body, and they, as well as the cell body, constitute the receptive surfaces of the target neuron onto which the afferent connections make their synaptic connections.

Defeat Drugs and Live Free

Defeat Drugs and Live Free

Being addicted to drugs is a complicated matter condition that's been specified as a disorder that evidences in the obsessional thinking about and utilization of drugs. It's a matter that might continue to get worse and become disastrous and deadly if left untreated.

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