Treatment

There are currently no PCP ANTAGONISTS that are useful for treatment of PCP OVERDOSE. Symptomatic treatment may be given for suppressed breathing rates, fever, high blood pressure, and increased salivation. Convulsions are treated with DlAZEPAM. Elimination of the drug may be enhanced by making the urine more acidic and/or pumping stomach contents. Attempts to minimize environmental stimuli have helped to control violent and self-destructive behavior. Psychiatric care may be needed for an extensive psychotic phase that may follow overdose (Jaffe, 1989).

(SEE ALSO: Abuse Liability of Drugs: Testing in Animals; Addiction: Concepts and Definitions; Adjunctive Drug Taking; Aggression and Drugs; Fetus: Effect of Drugs on the; Phencyclidine (PCP): Adverse Effects; Research, Animal Model: Drug Discrimination Studies; Tolerance and Physical Dependence)

BIBLIOGRAPHY

Carroll, M. E. (1990). PCP and Hallucinogens. Advances in Alcohol and Substance Abuse, 9, 167-190. Conveney, J. R., & Sparber, S. B. (1990). Delayed effects of amphetamine or phencyclidine: Interaction of food deprivation, stress and dose. Pharmacological and Biochemical Behavior, 36, 443-449. Golden, N. L., ET AL. (1987). Neonatal manifestations of maternal phencyclidine exposure. Perinatal Medicine, 15, 185-191. Grant, K. A., ET AL. (1991). Ethanol-like discriminative stimulus effects of noncompetitive n-methyl-d-aspar-tate antagonists. Behavioural Pharmacology, 2, 8795.

Howard, J., Beckwith, L., & Rodning, C. (1990). Adaptive behavior in recovering female phencyclidine/ polysubstance abusers. NIDA Research Monograph, 101, 86-95.

JAFFE, J. H. (1989). Psychoactive substance abuse disorders. In H. I. Kaplan and B. J. Sadock (Eds.), Comprehensive textbook of psychiatry, 5th ed. Baltimore: Williams & Wilkins. Phencyclidine hydrochloride (1999). Clinical Reference Systems, 1141. Slifer, B. L., Balster, R. L., & Woolmerton, W. L. (1984). Behavioral dependence produced by continuous phencyclidine infusion in rhesus monkeys. Journal of Pharmacology and Experimental Therapies, 230, 339-406. Willetts, J., Balster, R. L., & Leander, J. D. (1990). The behavioral pharmacology of NMDA receptor antagonists. Tr. Pharmacol. Sci. 11, 423-428.

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