Substance Abuse And Mood Disorders

Nearly all substances of abuse have the potential to alter mood symptoms. Classically, Psychostimulants, such as Amphetamines and COCAINE, may induce an appearance of elevated mood, racing thoughts, increased energy, and sense of well-being. Individuals who have developed tolerance to stimulants will experience, upon their discontinuation, withdrawal. These withdrawal symptoms will overlap characteristic depressive symptoms, including severe dysphoria, insomnia followed by hypersomnia, irritability, and fatigue. OPIATES induce a sense of elevated mood, and increased self-esteem. A sense of decreased anxiety is also frequently reported. Upon withdrawal, depressive symptoms are accompanied by characteristic physical symptoms such as muscle aches, drug CRAVING, lacrimation (secretion of tears), and piloerection (goose flesh).

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