Primarily used for therapeutic management of severe pain, the OPIOIDS can have a profound mood-altering euphoric effect that can lead to dependence. Administration of opioids (HEROIN, MORPHINE, or Demerol) to relatively naive users leads to a generalized depression of cognition that can be referred to as ''mental clouding.'' Impairments in perception, learning and memory, and reasoning accompany the drowsiness and mood changes induced by the drug. Generally, tolerance develops to the depression in mentation with chronic administration. Thus, there appears to be little long-term performance or brain dysfunction associated with this drug class.

Drug Addiction

Drug Addiction

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