Nausea And Vomiting

Nausea and vomiting are common side effects associated with the use of opioid analgesics. These effects are experienced following administration of opioids orally, by injection, or by injection into the spinal canal (epidurally)—they are worsened by movement and the resulting stimulation of the vestibular (inner ear organ responsible for balance). The site and mechanism responsible for these actions of opioids is presumed to be a special area in the brain stem or medulla, the chemoreceptive trigger zone of the area postrema.

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